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5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate

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5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate Basic information

Product Name:
5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate
Synonyms:
  • 5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate
  • 1-[BIS(DIMETHYLAMINO)METHYLEN]-5-CHLOROBENZOTRIAZOLIUM 3-OXIDE HEXAFLUOROPHOSPHATE
  • 1-[BIS(DIMETHYLAMINO)METHYLENE]-5-CHLORO-1H-BENZOTRIAZOLIUM 3-OXIDE HEXAFLUOROPHOSPHATE
  • 1-[BIS-(DIMETHYLAMINO)-METHYLENE]-5-CHLORO-1H-BENZOTRIAZOLIUM HEXAFLUOROPHOSPHATE 3-OXIDE
  • 1-(BIS-DIMETHYLAMINO-METHYLENE)-5-CHLORO-3-OXY-1H-BENZOTRIAZOL-1-IUM HEXAFLUOROPHOSPHATE
  • 2-(6-CHLORO-1-H-BENZOTRIAZOLE-1-YL)-1,1,3,3-TETRAMETHYLAMINIUM HEXAFLUOROPHOSPHATE
  • 1H-BENZOTRIAZOLIUM 1-[BIS(DIMETHYLAMINO)METHYLENE]-5CHLORO-,HEXAFLUOROPHOSPHATE (1-),3-OXIDE
  • 2-(1H-6-CHLOROBENZOTRIAZOLE-1-YL)-1,1,3,3-TETRAMETHYL-URONIUM HEXAFLUOROPHOSPHATE
CAS:
330645-87-9
MF:
C11H15ClF6N5OP
MW:
413.69
EINECS:
608-825-3
Product Categories:
  • Condensation & Active Esterification
  • Coupling Reactions (Peptide Synthesis)
  • Biochemistry
  • Peptide Synthesis
  • Synthetic Organic Chemistry
  • Peptide
  • Peptide coupling agents
  • Peptide Coupling Reagents
Mol File:
330645-87-9.mol
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5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate Chemical Properties

Melting point:
185-190 °C
storage temp. 
Store at +2°C to +8°C.
solubility 
soluble in Dimethylformamide
form 
powder to crystal
color 
White to Almost white
InChIKey
ZHHGTMQHUWDEJF-UHFFFAOYSA-N
CAS DataBase Reference
330645-87-9(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
3
10
HS Code 
29339990

MSDS

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5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate Usage And Synthesis

Chemical Properties

White powder

Uses

Reagent for:
Synthesis of near-infrared pH activatable fluorescent probes
Synthesis of human β-amyloid by Fmoc chemistry
Stereoselective Horner-Wadsworth-Emmons olefination
Covalent ligation of fluorescent peptides to quantum dots
Alkylation of human telomere sequence

General Description

HCTU [1] is a novel aminium-based coupling reagent, analogous to HBTU, which in comparative studies was found to give superiort results to TBTU in the synthesis of difficult peptides [2], in hindered couplings [3], and cyclizations [4].

The product number for this product was previously 01-62-0038.

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