4-Bromobenzoyl chloride Chemical Properties

Melting point:

36-39 °C(lit.)

Boiling point:

246 °C

Density 

1.6111 (rough estimate)

refractive index 

1.5963 (estimate)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

Chloroform, Methanol (Slightly)

form 

Low Melting Solid

color 

White to light brown

Water Solubility 

Soluble in methanol. Reacts with water forming Hcl.

Sensitive 

Moisture Sensitive

BRN 

636641

Stability:

Moisture Sensitive

CAS DataBase Reference

586-75-4(CAS DataBase Reference)

NIST Chemistry Reference

Benzoyl chloride, 4-bromo-(586-75-4)

EPA Substance Registry System

Benzoyl chloride, 4-bromo- (586-75-4)

Safety Information

Hazard Codes 

C

Risk Statements 

34-37

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3261 8/PG 2

WGK Germany 

3

F 

19-21

TSCA 

Yes

HazardClass 

8

PackingGroup 

II

HS Code 

29163900

MSDS

• Language:English Provider:4-Bromobenzoyl chloride
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-Bromobenzoyl chloride Usage And Synthesis

Chemical Properties

White to light brown low melting solid

Uses

4-Bromobenzoyl chloride is used in the synthesis of HIV-1 protease inhibitors. It is also used in the synthesis of oxazoles, cyclohexanone derivatives as analgesic and antimicrobial agents.

Purification Methods

Check IR of a film to see if OH bands are present. If absent then recrystallise from pet ether and dry it in vacuo. If OH bands are weak, then distil it in vacuo and recrystallise if necessary. If OH bands are very strong, then treat with an equal volume of redistilled SOCl2 reflux for 2hours, then evaporate excess of SOCl2 and distil the residual oil or low melting solid. Store it in the dark away from moisture. LACHRYMATORY. [Martin & Partington J Chem Soc 1175 1936, Beilstein 9 IV 1023.]

4-Bromobenzoyl chloride(586-75-4)Related Product Information

• p-Toluoyl chloride
• Polyvinyl chloride
• 4'-Bromoacetophenone
• 2-Fluorobenzoyl chloride
• Calcium chloride
• Ferric chloride
• 4-Bromomethylbenzoic acid
• Choline chloride
• Sulfuryl chloride
• Ammonium chloride
• Benzoyl chloride
• Potassium chloride
• Sodium chloride
• o-Toluoyl chloride
• 4-Bromobenzoic acid
• 4-tert-Butylbenzoyl chloride
• 4-Bromobenzenesulfonyl chloride
• 4-Chlorobenzoyl chloride