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Prednisone 21-acetate

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Prednisone 21-acetate Basic information

Product Name:
Prednisone 21-acetate
Synonyms:
  • 17 ALPHA,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE-21-ACETATE
  • 1-DEHYDROCORTISONE ACETATE
  • 1,4-PREGNADIEN-17,21-DIOL-3,11,20-TRIONE 21-ACETATE
  • 1,4-PREGNADIEN-17ALPHA,21-DIOL-3,11,20-TRIONE 21-ACETATE
  • [2-[(8s,9s,10s,13s,14s,17r)-17-hydroxy-10,13-dimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate
  • Dehydrocortisone acetate
  • prednisone 21-acetate
  • PREDNISONE ACETATE
CAS:
125-10-0
MF:
C23H28O6
MW:
400.46
EINECS:
204-726-0
Product Categories:
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids
  • 125-10-0
Mol File:
125-10-0.mol
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Prednisone 21-acetate Chemical Properties

Melting point:
240-242°C (dec.)
alpha 
D25 +186° (dioxane)
Boiling point:
582.0±50.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), Dioxane (Sparingly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
12.31±0.60(Predicted)
color 
White to Off-White
Water Solubility 
23mg/L(25 ºC)
CAS DataBase Reference
125-10-0(CAS DataBase Reference)
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Prednisone 21-acetate Usage And Synthesis

Chemical Properties

White Solid

Uses

Adrenocortical steroid antiinflammatory.

Definition

ChEBI: Cortancyl is a steroid ester, a 20-oxo steroid, an acetate ester, a 17alpha-hydroxy steroid, an 11-oxo steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It is functionally related to a prednisone.

in vivo

Prednisone acetate (5 mg/kg, Intragastric gavage, once a day for 4 weeks) induces hippocampal LTP impairment by causing neuronal lesions in the dentate gyrus, which reduced glutamic acid (Glu) and NMDAR2A, and impaired spatial memory in Hippocampal LTP impairment model mice[1].
Prednisone acetate (6 mg/kg, gavage, once a day for 15 days) reduces ocular and peripheral inflammatory responses and restores Th1/Th2 and Th17/Treg immune homeostasis through orchestrating the Notch signaling pathway in Experimental autoimmune uveitis (EAU) rats[2].

Animal Model:C57BL/6 mice [1]
Dosage:5 mg/kg
Administration:Intragastric gavage (i.g.)
Result:Significantly failed to gain weight. Decreased the population spike (%) after high-frequency stimulation. Reduced the crossing times compared with the control group. Resulted in the impairment of memory, and caused a trend of more serious impairment. Reduced the levels of Glu and gamma-aminobutyric acid (GABA) in the hippocampus. Reduced the expressions of N-methyl-D-aspartate receptors in the hippocampus.
Animal Model:Experimental autoimmune uveitis [2]
Dosage:6 mg/kg
Administration:gavage
Result:Showed fewer manifestations in eyes from day 9 after immunization. Reduced the inflammation in EAU rats. Bound with the pocket of Notch signaling-related molecules with good affinity. Exhibited anti-inflammatory effects through inhibiting Notch signaling activation. Decreased Th1, Th17 and increased Th2, Treg frequencies in EAU.

IC 50

IL-17; IL-10; IL-4

Prednisone 21-acetate Preparation Products And Raw materials

Raw materials

Selenium dioxide Cortisone acetate

Prednisone 21-acetateSupplier

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