3-(4-Pyridine)acrylic acid Chemical Properties

Melting point:

276-280°C

Boiling point:

317.5±17.0 °C(Predicted)

Density 

1.261±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

pka

3.13±0.10(Predicted)

Appearance

White to off-white Solid

BRN 

1719967

CAS DataBase Reference

84228-93-3(CAS DataBase Reference)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36

MSDS

• Language:English Provider:ALFA

3-(4-Pyridine)acrylic acid Usage And Synthesis

Synthesis

A. Preparation of (E)-3-(pyridin-4-yl)acrylic acid 4-Pyridinecarboxaldehyde (18.96 g, 0.177 mol) and malonic acid (55.3 g, 0.53 mol) were dissolved in 200 mL of pyridine. Piperidine (5.25 mL, 0.053 mol) was added to the solution and the reaction mixture was subsequently heated to reflux for 6 hours. After completion of the reaction, the mixture was cooled in an ice bath and the precipitated white solid was separated by filtration and washed with ether and dried to give 20.1 g of (E)-3-(pyridin-4-yl)acrylic acid. The filtrate was further concentrated, filtered again and washed with aqueous ethyl ether to afford an additional 2.2 g of product in a total yield of 84%.

References

[1] Patent: EP846687, 1998, A1
[2] Patent: US5972972, 1999, A
[3] Patent: US5618939, 1997, A

3-(4-Pyridine)acrylic acid(84228-93-3)Related Product Information

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• 4-Pyridineacrylic acid