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2-Aminopyrimidine

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2-Aminopyrimidine Basic information

Product Name:
2-Aminopyrimidine
Synonyms:
  • PYRIMIDIN-2-AMINE
  • PYRIMIDIN-2-YLAMINE
  • TIMTEC-BB SBB004387
  • 1,2-dihydro-2-imine-pyrimidin
  • 2-amino-pyrimidin
  • 2-pyridiylamine
  • 2-Pyrimidinemine
  • pyrimidin-2-amine analogue
CAS:
109-12-6
MF:
C4H5N3
MW:
95.1
EINECS:
203-648-4
Product Categories:
  • Heterocyclic Building Blocks
  • Pyrimidines
  • PYRIMIDINE
  • FINE Chemical & INTERMEDIATES
  • APIs & Intermediate
  • Building Blocks
  • Amines
  • Nucleic acids
  • C4 to C5
  • Chemical Synthesis
  • 109-12-6
Mol File:
109-12-6.mol
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2-Aminopyrimidine Chemical Properties

Melting point:
122-126 °C (lit.)
Boiling point:
158 °C (139.5186 mmHg)
Density 
1.1031 (rough estimate)
refractive index 
1.5200 (estimate)
Flash point:
103 °C
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Powder
pka
3.45(at 20℃)
color 
White to light yellow
Water Solubility 
SOLUBLE
BRN 
107014
InChIKey
LJXQPZWIHJMPQQ-UHFFFAOYSA-N
CAS DataBase Reference
109-12-6(CAS DataBase Reference)
EPA Substance Registry System
2-Pyrimidinamine (109-12-6)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
RIDADR 
UN 2811
WGK Germany 
3
RTECS 
UV6326000
F 
8
TSCA 
Yes
HS Code 
29335995

MSDS

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2-Aminopyrimidine Usage And Synthesis

Chemical Properties

white to light yellow powder

Uses

2-Aminopyrimidine is used in the synthesis of sulfonamides as isoform-selective inhibitors with efficacy in rodent pain models.

Definition

ChEBI: An aminopyrimidine carrying an amino group at position 2.

Synthesis Reference(s)

Tetrahedron Letters, 39, p. 1313, 1998 DOI: 10.1016/S0040-4039(97)10877-2

Purification Methods

Crystallise 2-aminopyrimidine from *C6H6, EtOH or H2O. [Beilstein 25 III/IV 2071.]

2-Aminopyrimidine Preparation Products And Raw materials

Raw materials

Sodium hydroxideZINCGuanidine hydrochlorideGuanidine nitrateMucochloric acidZINC HYDROXIDEDIETHOXYMETHANE6,7,8-Trifluoro-1,4-dihydrogen-4-oxo-quinoline-3-carboxylate ethyl esterpropargyl aldehyde5-Chloropyrimidin-2-amine

Preparation Products

Buspirone5-BROMO-2-(DIMETHYLAMINO)PYRIMIDINE5-BROMO-2-(METHYLAMINO)PYRIMIDINE5-BROMO-2-FLUOROPYRIMIDINEPrimisulfuron-methyl2-CHLORO-PYRIMIDINE-5-SULFONYL CHLORIDE

2-AminopyrimidineSupplier

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