1-BENZOYL-3-PHENYL-2-THIOUREA
1-BENZOYL-3-PHENYL-2-THIOUREA Basic information
- Product Name:
- 1-BENZOYL-3-PHENYL-2-THIOUREA
- Synonyms:
-
- N-[anilino(sulfanylidene)methyl]benzamide
- 1-benzoyl-3-phenyl-2-thio-ure
- n-phenylthiocarbamoyl-benzamid
- phenylbenzoylthiourea
- usafk-1473
- 1-Benzoyl-3-phenyl(thiourea)
- 1-Benzoyl-3-phenylthiourea
- N-(Phenylthiocarbamoyl)benzamide
- CAS:
- 4921-82-8
- MF:
- C14H12N2OS
- MW:
- 256.32
- Mol File:
- 4921-82-8.mol
1-BENZOYL-3-PHENYL-2-THIOUREA Chemical Properties
- Melting point:
- 159 °C
- Density
- 1.290±0.06 g/cm3(Predicted)
- storage temp.
- -20°
- solubility
- Soluble in DMSO (greater than 50 mg/ml) or in Ethanol (up to 8 mg/ml).
- form
- solid
- pka
- 9.49±0.70(Predicted)
- color
- Off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
- CAS DataBase Reference
- 4921-82-8(CAS DataBase Reference)
1-BENZOYL-3-PHENYL-2-THIOUREA Usage And Synthesis
Description
TM-2-51 (4921-82-8) is a highly potent and isozyme selective activator of recombinant HDAC8. Increases the activity of HDAC8 by a factor of 12 at 10 μM. No activation of other HDACs is observed. TM-2-51 rescues the activity of catalytically compromised HDAC8 mutants?in vitro.2
References
1) Singh?et al. (2011), Histone deacetylase activators: N-acetylthioureas as highly potent and isozyme selective activators for human histone deacetylase-8 on a fluorescent substrate; Bioorg. Med. Chem. Lett.,?21?5920 2) Decross?et al. (2014), Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders; ACS Chem. Biol.,?9?2157 3) Singh?et al. (2015),?Mechanism of N-acylthiourea Mediated Activation of Human Histone Deacetylase 8 (HDAC8) at Molecular and Cellular Levels; J. Biol. Chem.,?290?6607
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