3-CHLORO-2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE Chemical Properties

Melting point:

159-161 °C (lit.)

Boiling point:

234.6±40.0 °C(Predicted)

Density 

1.53±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

form 

Solid

pka

8.06±0.10(Predicted)

Appearance

White to off-white Solid

CAS DataBase Reference

76041-71-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

T,Xi

Risk Statements 

25-36/37/38

Safety Statements 

26-36/37-45

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29333990

MSDS

• Language:English Provider:SigmaAldrich

3-CHLORO-2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE Usage And Synthesis

Uses

3-Chloro-5-(trifluoromethyl)pyridin-2(3H)-one is a useful research chemical.

Chemical Properties

White to light yellow solid

Synthesis

General procedure for the synthesis of 3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine from 2-hydroxy-5-(trifluoromethyl)pyridine: 2-hydroxy-5-(trifluoromethyl)pyridine (15.3 g, 0.094 mol) and N-chlorosuccinimide (14.4 g, 0.108 mol) were dissolved in 50 mL of anhydrous N,N-dimethylformamide (DMF) and nitromethane in a in a mixed solvent. The reaction mixture was stirred at room temperature for 8 hours. After the reaction was completed, the reaction solution was slowly poured into 250 mL of water and a light yellow precipitate was precipitated. The precipitate was collected by filtration and dried to give 17.1 g (0.087 mol) of 3-chloro-5-trifluoromethyl-2-hydroxypyridine in 92% yield.

References

[1] Patent: CN102875453, 2016, B. Location in patent: Paragraph 0025

3-CHLORO-2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE(76041-71-9)Related Product Information

• 2-Hydroxy-5-trifluoromethylpyridine
• 3-CHLORO-2-[4-(ETHOXYCARBONYL)PHENOXY]-5-(TRIFLUOROMETHYL)PYRIDINE
• 4-[(3-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)ANILINO)METHYL]-1(2H)-PHTHALAZINONE
• 1-(4-CHLOROPHENYL)-1-ETHANONE O-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXIME
• 3-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)PHENYL 3-(TRIFLUOROMETHYL)BENZENESULFONATE
• 4-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)-N-[(DIMETHYLAMINO)METHYLENE]BENZENECARBOXAMIDE
• 3-[(3-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)ANILINO)METHYLENE]-2-BENZOFURAN-1(3H)-ONE
• 3-CHLORO-2-[2-(1,3,4-OXADIAZOL-2-YL)PHENOXY]-5-(TRIFLUOROMETHYL)PYRIDINE
• 3-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)PHENYL 3-(2-CHLOROPHENYL)-5-METHYL-4-ISOXAZOLECARBOXYLATE
• 3-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)PHENYL 4-METHYLBENZENESULFONATE
• 3-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)PHENYL 4-CHLOROBENZENECARBOXYLATE
• 3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL 4-(5H-THIENO[2,3-C]PYRROL-5-YL)PHENYL ETHER
• 2-[5-(4-CHLOROPHENYL)-1,3,4-OXADIAZOL-2-YL]PHENYL 3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL ETHER
• (4-(3-CHLORO-5-(TRIFLUOROMETHYL)(2-PYRIDYLOXY))PHENYL)(HYDROXYIMINO)METHYLAMINE
• 3-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)PHENYL 2-CHLOROBENZENESULFONATE
• 3-CHLORO-2-[4-(1H-PYRROL-1-YL)PHENOXY]-5-(TRIFLUOROMETHYL)PYRIDINE
• 4-[(4-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)ANILINO)METHYL]-1(2H)-PHTHALAZINONE
• 4-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)-N-(([(2,4-DICHLOROBENZYL)OXY]IMINO)METHYL)BENZENECARBOXAMIDE