SIB 1893
SIB 1893 Basic information
- Product Name:
- SIB 1893
- Synonyms:
-
- SIB 1893
- 2-METHYL-6-(2-PHENYLETHENYL)PYRIDINE
- (E)-2-METHYL-6-(2-PHENYLETHYL)-PYRIDINE
- (E)-2-METHYL-6-STYRYL-PYRIDINE
- 2-Methyl-6-[(E)-2-phenylethenyl]pyridine
- NSC 36665
- Pyridine, 2-methyl-6-(2-phenylethenyl)-
- (E/Z)-SIB-1893
- CAS:
- 6266-99-5
- MF:
- C14H13N
- MW:
- 195.26
- Product Categories:
-
- Glutamate receptor
- Mol File:
- 6266-99-5.mol
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SIB 1893 Chemical Properties
- storage temp.
- 2-8°C
- solubility
- DMSO: 18 mg/mL
- form
- solid
- color
- White to off-white
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MSDS
- Language:English Provider:SigmaAldrich
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SIB 1893 Usage And Synthesis
Uses
SIB 1893 is a selective antagonist of mGluR-5. SIB 1893 acts as a positive allosteric modulator of human metabotropic mGlu4 (1). Anticonvulsant (2).
Definition
ChEBI: 2-methyl-6-(2-phenylethenyl)pyridine is a member of styrenes.
Biological Activity
A highly selective non-competitive antagonist for the metabotropic glutamate mGlu 5 receptor subtype; displays an IC 50 value of 0.3 μ M? at hmGlu 5 , compared with > 100 μ M at hmGlu 1b , hmGlu 2 , hmGlu 6 , hmGlu 7 and hmGlu 8 . Centrally active upon systemic administration in vivo . Positive allosteric modulator at mGlu 4 receptors.
SIB 1893Supplier
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
Hangzhou Yuhao Chemical Technology Co., Ltd
- Tel
- 0571-82693216
- info@yuhaochemical.com
HangZhou YuHao Chemical Technology Co., Ltd.
- Tel
- 0571-82693216
- info@yuhaochemical.com
AdooQ Bioscience CHINA
- Tel
- 025-58849295 18951903616;
- info@adooq.cn
Capot Chemical Co.,Ltd.
- Tel
- +86-（0）57185586718 +86-13336195806
- sales@capot.com
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SIB 1893(6266-99-5)Related Product Information
- ETHYLENE
- stilbazium iodide
- SIB 1893
- 4-(1,3-BENZODIOXOL-5-YL)-2-[(E)-2-(3-NITROPHENYL)ETHENYL]-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE
- 4-(1,3-BENZODIOXOL-5-YL)-2-(4-METHOXYSTYRYL)-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE
- 4-(1,3-BENZODIOXOL-5-YL)-2-[(E)-2-(3-BROMOPHENYL)ETHENYL]-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE
- 4-(1,3-BENZODIOXOL-5-YL)-2-[(E)-2-(2-CHLOROPHENYL)ETHENYL]-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE
- 2-[(E)-2-(4-FLUOROPHENYL)ETHENYL]-5-OXO-4-(3,4,5-TRIMETHOXYPHENYL)-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE
- 4-(1,3-BENZODIOXOL-5-YL)-2-[(E)-2-(3-CHLOROPHENYL)ETHENYL]-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE
- 4-(1,3-BENZODIOXOL-5-YL)-2-(3,4-DICHLOROSTYRYL)-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE
- 4-(1,3-BENZODIOXOL-5-YL)-2-[(E)-2-(4-FLUOROPHENYL)ETHENYL]-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE
- 4-(1,3-BENZODIOXOL-5-YL)-2-[(E)-2-(4-CHLOROPHENYL)ETHENYL]-5H-INDENO[1,2-B]PYRIDIN-5-ONE
- 4-(2-FLUOROPHENYL)-2-[(E)-2-(3-METHOXYPHENYL)ETHENYL]-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE
- 2-[(E)-2-(3-CHLOROPHENYL)ETHENYL]-4-(4-HEPTYLPHENYL)-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE
- 4-(1,3-BENZODIOXOL-5-YL)-2-[(E)-2-(2-FLUOROPHENYL)ETHENYL]-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE
- 4-(1,3-BENZODIOXOL-5-YL)-2-(4-HYDROXYSTYRYL)-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE
- 4-(1,3-BENZODIOXOL-5-YL)-2-(4-NITROSTYRYL)-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE