1,3-DIMETHYL-4-NITRO-1H-PYRAZOLE Chemical Properties

Melting point:

72 °C

Boiling point:

243.0±20.0 °C(Predicted)

Density 

1.36±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

form 

powder

pka

-1.60±0.10(Predicted)

color 

White

Safety Information

HazardClass 

IRRITANT

HS Code 

2933199090

1,3-DIMETHYL-4-NITRO-1H-PYRAZOLE Usage And Synthesis

Synthesis

General method: 4-Iodo-1,3-dimethyl-1H-pyrazole (1 mmol) was dissolved in tetrahydrofuran (THF, 10 mL) and Fuajasite catalyst (250 mg) was added. Concentrated nitric acid (density 1.52 g/cm3, 10 mL) was added slowly and the reaction was stirred at room temperature for the desired time. After completion of the reaction, the catalyst was recovered by filtration and the filtrate was extracted with dichloromethane several times. The organic phases were combined and concentrated under reduced pressure to remove the solvent to give 1,3-dimethyl-4-nitro-1H-pyrazole.

References

[1] Synthetic Communications, 2012, vol. 42, # 23, p. 3463 - 3471
[2] Russian Chemical Bulletin, 1996, vol. 45, # 11, p. 2581 - 2584
[3] Catalysis Communications, 2013, vol. 42, p. 35 - 39