4-Bromo-1,2-(methylenedioxy)benzene Chemical Properties

Boiling point:

85-86 °C1 mm Hg(lit.)

Density 

1.669 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.583(lit.)

Flash point:

>230 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform, Methanol (Sparingly)

form 

Liquid

Specific Gravity

1.669

color 

Clear yellow-orange

BRN 

127407

Stability:

Light Sensitive

InChI

InChI=1S/C7H5BrO2/c8-5-1-2-6-7(3-5)10-4-9-6/h1-3H,4H2

InChIKey

FBOYMIDCHINJKC-UHFFFAOYSA-N

SMILES

O1C2=CC=C(Br)C=C2OC1

CAS DataBase Reference

2635-13-4(CAS DataBase Reference)

NIST Chemistry Reference

4-Bromo-1,2-(methylenedioxy)benzene(2635-13-4)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29329990

MSDS

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4-Bromo-1,2-(methylenedioxy)benzene Usage And Synthesis

Chemical Properties

clear yellow-orange liquid

Synthesis Reference(s)

Tetrahedron, 64, p. 4999, 2008 DOI: 10.1016/j.tet.2008.03.085

General Description

The coupling of 1-bromo-3,4-(methylenedioxy)benzene with β-methallyl alcohol was catalyzed by Pd(OAc)₂ in combination with P(t-Bu)₃.

Synthesis

NBS (1.87 g, 10.50 mmol, 1.05 equiv.), HPLC-grade acetonitrile and benzo[d][1,3]dioxole (10 mmol) were placed into a flask and stirred until completely homogeneous. The solution was pumped through the Corning G1 photoreactor at the desired flow rate. The reaction mixture was collected from the reactor and combined with the two separate streams of toluene and water into a 10-mL Vapourtec static mixer coil; then, the mixture was pumped into a Zaiput liquid-liquid membrane separator, the organic phase was collected and passed twice more through the Zaiput membrane separator. The organic phase was evaporated under reduced pressure, providing the corresponding brominated product 4-Bromo-1,2-(methylenedioxy)benzene.

4-Bromo-1,2-(methylenedioxy)benzene(2635-13-4)Related Product Information

• Ethylbenzene
• 1,3-Dibromobenzene
• 1,2-Dibromobenzene
• Bromoxynil
• 1,3-Benzodioxole
• 3-Methoxybenzaldehyde
• 3-Bromoanisole
• 4-Methoxyphenylacetic acid
• Benzene
• Anisole
• 4-Methoxybenzoic acid
• p-Anisaldehyde
• Allylbenzene
• 3-(Trifluoromethoxy)bromobenzene
• m-Anisyl alcohol
• (3-Methoxyphenyl)acetonitrile
• (Trifluoromethoxy)benzene
• 4'-Bromopropiophenone