2-Chloroquinoline Chemical Properties

Melting point:

34-37 °C (lit.)

Boiling point:

266-267 °C (lit.)

Density 

1.23 g/mL at 25 °C (lit.)

refractive index 

1.6342 (estimate)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

methanol: 0.1 g/mL, clear

form 

Crystalline Powder, Crystals and/or Chunks or Fused Mass

pka

0.41±0.40(Predicted)

color 

White to yellow

Water Solubility 

Insoluble

BRN 

112561

InChIKey

OFUFXTHGZWIDDB-UHFFFAOYSA-N

CAS DataBase Reference

612-62-4(CAS DataBase Reference)

NIST Chemistry Reference

Quinoline, 2-chloro-(612-62-4)

EPA Substance Registry System

Quinoline, 2-chloro- (612-62-4)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

RTECS 

VB2320000

F 

8

TSCA 

Yes

HS Code 

29334900

MSDS

• Language:English Provider:2-Chloroquinoline
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Chloroquinoline Usage And Synthesis

Chemical Properties

white to yellowish crystals, powder, chunks or

Uses

2-Chloroquinoline is an intermediate used in the synthesis of various compounds that exhibits antifungal properties.

Uses

2-Chloroquinoline is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. It reacts with benzotriazole, followed by cyclization with loss of nitrogen, gives the indolo[2,3-b]quinoline ring system for use in novel cytotoxic DNA topoisomerase II inhibitors.

Synthesis Reference(s)

The Journal of Organic Chemistry, 67, p. 7884, 2002 DOI: 10.1021/jo016196i
Synthesis, p. 1013, 1987 DOI: 10.1055/s-1987-28152

Purification Methods

Purify it by crystallisation of its picrate to constant melting point (123-124o) from *benzene, regenerating the base and distilling it under vacuum [Cumper et al. J Chem Soc 1183 1962]. 2-Chloroquinoline can be crystallised from EtOH. Its picrate has m 123-124o (from EtOH). [Beilstein 20 H 359, 20/7 V 312.]

2-Chloroquinoline(612-62-4)Related Product Information

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