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2-Chloroquinoline

Basic information Safety Supplier Related

2-Chloroquinoline Basic information

Product Name:
2-Chloroquinoline
Synonyms:
  • 2-chloro-quinolin
  • Quinoline2-chloro-
  • 2-CHLOROQUINOLINE
  • 2CQ
  • 2-Chloroquinoline,99%
  • 2-Chloroquinoline ,99.70%
  • 2-Chloroquinoline, 99% 1GR
  • 2-Chloroquinoline, 99% 5GR
CAS:
612-62-4
MF:
C9H6ClN
MW:
163.6
EINECS:
210-317-8
Product Categories:
  • Quinolines, Quinazolines and derivatives
  • Quinoline&Isoquinoline
  • Organohalides
  • Quinoline
  • Haloquinolines
  • Quinolines
  • Halides
  • Heterocycles
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • QuinolinesHeterocyclic Building Blocks
Mol File:
612-62-4.mol
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2-Chloroquinoline Chemical Properties

Melting point:
34-37 °C (lit.)
Boiling point:
266-267 °C (lit.)
Density 
1.23 g/mL at 25 °C (lit.)
refractive index 
1.6342 (estimate)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
methanol: 0.1 g/mL, clear
form 
Crystalline Powder, Crystals and/or Chunks or Fused Mass
pka
0.41±0.40(Predicted)
color 
White to yellow
Water Solubility 
Insoluble
BRN 
112561
InChIKey
OFUFXTHGZWIDDB-UHFFFAOYSA-N
CAS DataBase Reference
612-62-4(CAS DataBase Reference)
NIST Chemistry Reference
Quinoline, 2-chloro-(612-62-4)
EPA Substance Registry System
Quinoline, 2-chloro- (612-62-4)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
RTECS 
VB2320000
8
TSCA 
Yes
HS Code 
29334900

MSDS

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2-Chloroquinoline Usage And Synthesis

Chemical Properties

white to yellowish crystals, powder, chunks or

Uses

2-Chloroquinoline is an intermediate used in the synthesis of various compounds that exhibits antifungal properties.

Uses

2-Chloroquinoline is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. It reacts with benzotriazole, followed by cyclization with loss of nitrogen, gives the indolo[2,3-b]quinoline ring system for use in novel cytotoxic DNA topoisomerase II inhibitors.

Synthesis Reference(s)

The Journal of Organic Chemistry, 67, p. 7884, 2002 DOI: 10.1021/jo016196i
Synthesis, p. 1013, 1987 DOI: 10.1055/s-1987-28152

Purification Methods

Purify it by crystallisation of its picrate to constant melting point (123-124o) from *benzene, regenerating the base and distilling it under vacuum [Cumper et al. J Chem Soc 1183 1962]. 2-Chloroquinoline can be crystallised from EtOH. Its picrate has m 123-124o (from EtOH). [Beilstein 20 H 359, 20/7 V 312.]

2-ChloroquinolineSupplier

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