HIPPURYL-HIS-LEU Chemical Properties

Boiling point:

912.4±65.0 °C(Predicted)

Density 

1.283±0.06 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

acetic acid: 50 mg/mL, clear, colorless

form 

powder

pka

3.26±0.10(Predicted)

color 

white to off-white

Safety Information

WGK Germany 

3

F 

10-21

HIPPURYL-HIS-LEU Usage And Synthesis

Chemical Properties

white fine crystalline powder

Uses

Hippuryl-His-Leu-OH is a substrate for detecting the activity of angiotensin I converting enzyme. The His-Leu released by Hippuryl-His-Leu-OH can react with o-phtbaldialdehyde or Fluorescamine (HY-D0715) for fluorescence detection[1][2][3].

References

[1] Nishimura K, et al. Purification of angiotensin I-converting enzyme from human lung. Biochim Biophys Acta. 1977 Aug 11;483(2):398-408. DOI:10.1016/0005-2744(77)90067-5
[2] Santos RA, et al. An improved fluorometric assay of rat serum and plasma converting enzyme. Hypertension. 1985 Mar-Apr;7(2):244-52. DOI:10.1161/01.hyp.7.2.244
[3] Horiuchi M, et al. Method for determination of angiotensin-converting enzyme activity in blood and tissue by high-performance liquid chromatography. J Chromatogr. 1982 Dec 10;233:123-30. DOI:10.1016/s0378-4347(00)81738-7

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