2,4-DIMETHYLPHENYLBORONIC ACID Chemical Properties

Melting point:

204-208°C

Boiling point:

292.4±50.0 °C(Predicted)

Density 

1.07±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

Water Solubility 

Slightly soluble in water

form 

powder to crystal

pka

8.92±0.58(Predicted)

color 

White to Light yellow

CAS DataBase Reference

55499-44-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-36/37/39-36/37-37

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29319090

MSDS

• Language:English Provider:ALFA

2,4-DIMETHYLPHENYLBORONIC ACID Usage And Synthesis

Chemical Properties

White powder

Uses

suzuki reaction

Synthesis

The general procedure for the synthesis of 2,4-dimethylphenylboronic acid from triisopropyl borate and 2,4-dimethylbromobenzene was as follows: 3.42 g (0.140 mol) of magnesium and 9 mL of tetrahydrofuran were added to a reaction vessel fitted with a dropping funnel under nitrogen protection. Subsequently, a solution consisting of 20.0 g (0.108 mol) of 2,4-dimethylbromobenzene dissolved in 60 mL of tetrahydrofuran (Eq. I-4-1) was added dropwise to prepare the Grignard reagent. After the reaction mixture was stirred for 2 hours, 14.6 g (0.140 mol) of trimethyl borate was added slowly and dropwise. After continued stirring for 2 hours, hydrochloric acid was added and stirred for 1 hour. Upon completion of the reaction, the organic layer was separated, washed with brine, and then the solvent was removed by distillation to afford 15.4 g (0.103 mol) of 2,4-dimethylphenylboronic acid (Formula I-4-2).

References

[1] Patent: JP2015/110532, 2015, A. Location in patent: Paragraph 0132-0133

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