Trichlormethiazide Chemical Properties

Melting point:

248-250℃

Boiling point:

631.3±65.0 °C(Predicted)

Density 

1.748

refractive index 

1.6000 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

pKa 6.9(acetone/H2O) (Uncertain)

color 

White to Off-White

Merck 

14,9624

CAS DataBase Reference

133-67-5(CAS DataBase Reference)

EPA Substance Registry System

Trichlormethiazide (133-67-5)

Safety Information

Hazard Codes 

Xn

Risk Statements 

42/43

Safety Statements 

36

WGK Germany 

2

RTECS 

DK8925000

HS Code 

2935904000

Hazardous Substances Data

133-67-5(Hazardous Substances Data)

Toxicity

LD50 orally in rats: >20000 mg/kg (Goldenthal)

MSDS

• Language:English Provider:SigmaAldrich

Trichlormethiazide Usage And Synthesis

Chemical Properties

Trichlormethiazide occurs as a white or practically white, crystalline powder and may have a slight characteristic odor.

Originator

Naqua,Schering,US,1960

Uses

diuretic, antihypertensive

Uses

Trichlormethiazide, is a diuretic, having similar properties as Hydrochlorothiazide (H714560). It is used for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension.

Uses

Trichlormethiazide is a diuretic and anti-hypertensive agent from the benzothiadiazide class which is used in veterinary medicine in cattle, sheep, goats, pigs and horses, at the following therapeutic regimen: a single intramuscular dose of 0.4 mg/kg bw followed by two oral doses of 0.8 mg/kg bw given 12 and 36 hours after the first administration.
Trichlormethiazide is also used in humans in the United States as a diuretic and anti-hypertensive substance but not in the European Union. The usual dose is 2 to 4 mg twice a day (i.e. approximately 0.033 to 0.066 mg/kg bw/day).

Definition

ChEBI: Trichlormethiazide is a benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension. It has a role as a diuretic and an antihypertensive agent. It is a benzothiadiazine and a sulfonamide antibiotic.

Manufacturing Process

A mixture of 5.7 grams (0.02 mol) of 5-chloro-2,4-disulfamylaniline and 4.9 grams (0.04 mol) of dichloroacetaldehyde in 25 ml of dimethyl formamide was heated at the boiling temperature and under reflux for 30 minutes. The reaction mixture was thereafter poured into a mixture of ice and water to precipitate the desired 6-chloro-7-sulfamyl-3-dichloromethyl-3,4-dihydro- 1,2,4-benzothiadiazine-1,1-dioxide as a crystalline solid melting at 250° to 270°C with decomposition.

Therapeutic Function

Diuretic

Trichlormethiazide(133-67-5)Related Product Information

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