Chlorotripyrrolidinophosphonium hexafluorophosphate Chemical Properties

Melting point:

145-148°C

storage temp. 

2-8°C

solubility 

soluble in Chloroform, Methanol

form 

Crystalline Powder

color 

White to yellow

Sensitive 

Moisture Sensitive

BRN 

6842341

InChI

InChI=1S/C12H24ClN3P.F6P/c13-17(14-7-1-2-8-14,15-9-3-4-10-15)16-11-5-6-12-16;1-7(2,3,4,5)6/h1-12H2;/q+1;-1

InChIKey

BSCYRXJVGSZNKX-UHFFFAOYSA-N

SMILES

[P+5]([F-])([F-])([F-])([F-])([F-])[F-].[P+](N1CCCC1)(N1CCCC1)(N1CCCC1)Cl

CAS DataBase Reference

133894-48-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,C

Risk Statements 

36/37/38-34

Safety Statements 

26-36-45-36/37/39

RIDADR 

UN 1759 8/PG 2

WGK Germany 

3

F 

10-21

HazardClass 

8

PackingGroup 

II

HS Code 

29339900

MSDS

• Language:English Provider:SigmaAldrich

Chlorotripyrrolidinophosphonium hexafluorophosphate Usage And Synthesis

Uses

Crystalline reagent for peptide coupling of a-alkylated N-Fmoc and N-Z-amino acids in high yield and without racemization.

Uses

Reagent for:
Peptide coupling reactions and synthesis of coupling reagents
Sequence selective peptide recognition
Synthesis of condensing reagents
Synthesis of heterocyclic β-sheet ligands

Preparation

Preparation of chlorotripyrrolidinophosphonium hexafluorophosphate: addition of chlorine to a diethyl ether solution of tripyrrolidinophosphine, then addition of KPF6 in water. Addition of tripyrrolidinophosphine oxide to a DCM solution of phosphoryl trichloride, then addition of KPF6 in water.

reaction suitability

reaction type: Coupling Reactions

Chlorotripyrrolidinophosphonium hexafluorophosphate(133894-48-1)Related Product Information

• Lithium hexafluorophosphate
• Potassium hexafluorophosphate
• Ammonium hexafluorophosphate
• Cetylpyridinium chloride monohydrate
• Hexafluorophosphoric acid
• BIS(DIETHYLAMINO)CHLOROPHOSPHINE
• TRIS(DIETHYLAMINO)PHOSPHINE
• BIS(DIMETHYLAMINO)CHLOROPHOSPHINE
• Chlorotripyrrolidinophosphonium hexafluorophosphate