1,4-Phenylene diisocyanate Chemical Properties

Melting point:

96-99 °C (lit.)

Boiling point:

260 °C (lit.)

Density 

1.3848 (rough estimate)

vapor pressure 

<0.01 mm Hg ( 20 °C)

refractive index 

1.4900 (estimate)

Flash point:

>230 °F

solubility 

THF: soluble

form 

powder to crystal

color 

White to Light yellow

Water Solubility 

130mg/L at 20℃

Stability:

Stable. Combustible. Incompatible with strong oxidising agents, strong alkalies, strong acids, alcohols, amines. Moisture sensitive.

LogP

3.19 at 20℃

CAS DataBase Reference

104-49-4(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1,4-diisocyanato-(104-49-4)

EPA Substance Registry System

1,4-Phenylene diisocyanate (104-49-4)

Safety Information

Hazard Codes 

Xn,C

Risk Statements 

20/21/22-36/37/38-42-34-41-38

Safety Statements 

22-26-36/37-45-36/37/39

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

CZ6150000

HazardClass 

6.1

PackingGroup 

III

HS Code 

29291010

MSDS

• Language:English Provider:1,4-Phenylene diisocyanate
• Language:English Provider:SigmaAldrich

1,4-Phenylene diisocyanate Usage And Synthesis

Chemical Properties

white to light yellow crystals

Uses

1,4-Phenylene diisocyanate has been used:

• as croos-linking reagent to investigate the mechanism of enzyme immobilization on silanized surfaces
• in the synthesis of dipodal bis-urea receptor, a selective receptor for hydrogen sulfate
• in deposition of polyurea resists films via molecular layer deposition

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 7, p. 177, 1970 DOI: 10.1002/jhet.5570070126

General Description

White crystals or pale yellow chunky solid. Pungent odor.

Air & Water Reactions

Reacts slowly with water to form CO2

Reactivity Profile

1,4-Phenylene diisocyanate is sensitive to moisture. 1,4-Phenylene diisocyanate is incompatible with water, strong acids, strong alkalis, strong oxidizers, alcohol, amines and other hydrogen compounds.

Fire Hazard

1,4-Phenylene diisocyanate is combustible.

Flammability and Explosibility

Not classified

1,4-Phenylene diisocyanate(104-49-4)Related Product Information

• Isophorone diisocyanate
• Hexamethylene Diisocyanate
• p-Phenylenediamine
• 4-Aminobenzoic acid
• Sulfanilic acid
• 4-Biphenylcarboxaldehyde
• TEREPHTHALIC ACID DIALLYL ESTER
• 4,4'-Methylenedi-p-phenylene diisocyanate,METHYLENE DI-P-PHENYLENE DIISOCYANATE,Methylenebis(1,4-phenylene) diisocyanate,Methylenebis(1,4-phenylene)diisocyanate
• Tolylene-2,4-diisocyanate
• TOLYLENE 2,5-DIISOCYANATE
• METHYLISOCYANATE 1 X 500MG NEAT
• Phenyl isocyanate
• METHYLENE DI-P-PHENYLENE DIISOCYANATE
• 1-N-PROPYLPIPERAZINE DIHYDROBROMIDE
• 4-CHLORO-6-METHYL-1,3-PHENYLENE DIISOCYANATE,4-CHLORO-6-METHYL-M-PHENYLENE DIISOCYANATE
• 1-PROPYLPIPERAZINE
• 2-METHYL-M-PHENYLENE DIISOCYANATE
• 2,4,6-TRIMETHYL-1,3-PHENYLENE DIISOCYANATE