3-Bromo-5-fluoroanisole Chemical Properties

Boiling point:

94 °C / 17mmHg

Density 

1.59

refractive index 

1.5360-1.5400

storage temp. 

2-8°C

form 

clear liquid

color 

Colorless to Light yellow

Sensitive 

Light Sensitive

InChIKey

XVNQVSGOIUYOPB-UHFFFAOYSA-N

CAS DataBase Reference

29578-39-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

F,Xi,Xn

Risk Statements 

22

RIDADR 

1993

HazardClass 

IRRITANT

PackingGroup 

Ⅲ

HS Code 

2909303890

3-Bromo-5-fluoroanisole Usage And Synthesis

Chemical Properties

Colorless transparent liquid

Uses

3-fluoro-5-bromoanisole is an ether organic substance, which can be used as a pharmaceutical intermediate. 

Synthesis

1. 1-Bromo-3,5-difluorobenzene (10 g, 0.052 mol) was dissolved in anhydrous DMF (300 mL) at 0-5 °C. 2. Sodium methanol (5.60 g, 0.1036 mol) was added to the above solution. 3. The reaction mixture was stirred at room temperature for 24 h. 4. Upon completion of the reaction, the reaction mixture was extracted three times with ethyl acetate. 5. The organic layers were combined, washed with brine and then dried with anhydrous Na2SO4. 6. The solvent was removed by evaporation to give 3-bromo-5-fluoroanisole (7.5 g, 71% yield).

References

[1] Patent: US2008/261941, 2008, A1. Location in patent: Page/Page column 43
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 2, p. 758 - 766
[3] Journal of Medicinal Chemistry, 1997, vol. 40, # 11, p. 1634 - 1647

3-Bromo-5-fluoroanisole(29578-39-0)Related Product Information

• 2-Bromoanisole
• Transfluthrin
• Anisole
• Florfenicol
• 3-Bromoanisole
• 2-Bromofluorobenzene
• 4-Fluoroanisole
• 4-Fluorobenzaldehyde
• 4'-Bromopropiophenone
• 4-Bromofluorobenzene
• Bromoxynil
• 4-Bromoanisole
• 3-BROMO-5-FLUOROBENZALDEHYDE
• 1,3-Dibromobenzene
• Bromine
• 4-Bromo-2-fluoro-6-methoxyphenylboronic acid
• 5-Bromo-2,3-difluoroanisole
• FENFLURAMINE