3'-DT CEP
3'-DT CEP Basic information
- Product Name:
- 3'-DT CEP
- Synonyms:
-
- 3'-Deoxy-5'-O-DMT-5-methyluridine 2'-CE phosphoramidite
- 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-3'-deoxy-5-methyluridine 2'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
- 5-METHYL-3'-DU CEP
- 3'-DT CEP
- 5-Me-3'-dU-2'-phosphoramidite
- Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-deoxy-5-methyl-, 2'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
- 5’-O-(4,4-Dimethoxytrityl)-3’-deoxy-5-methyl uridine-2’-CED-phosphoramidite
- Diisopropyl-phosphoramidous acid (2R,3R,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester
- CAS:
- 142103-12-6
- MF:
- C40H49N4O8P
- MW:
- 744.81
- Mol File:
- 142103-12-6.mol
3'-DT CEP Chemical Properties
- solubility
- DMSO: Sparingly soluble: 1-10 mg/ml
Ethanol: Sparingly soluble: 1-10 mg/ml - pka
- 9.55±0.10(Predicted)
3'-DT CEP Usage And Synthesis
Uses
5-Me-3’-dU-2’-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
References
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
[2] TAKASHI OSAWA. Synthesis and hybridizing properties of isoDNAs including 3′-O,4′-C-ethyleneoxy-bridged 5-methyluridine derivatives[J]. Bioorganic & Medicinal Chemistry, 2018, 26 14: Pages 3875-3881. DOI: 10.1016/j.bmc.2018.05.043
[3] CARMELO J. RIZZO Ronald B ∗ Joseph P Dougherty. 3′-Deoxy-2′-phosphoramidites of adenosine and 5-methyluridine used for the solid phase synthesis of unnatural 3′-deoxy-2′–5″-Oligonucleotides.[J]. Tetrahedron Letters, 1992, 33 29: Pages 4129-4132. DOI: 10.1016/s0040-4039(00)74670-3
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