SPINOSAD Chemical Properties

Melting point:

110℃

storage temp. 

0-6°C

solubility 

Ethanol: 1 mg/ml

EPA Substance Registry System

Spinosad (168316-95-8)

Safety Information

Hazard Codes 

N

Risk Statements 

50/53

Safety Statements 

61

RIDADR 

UN3077 9/PG 3

WGK Germany 

3

Toxicity

LD50 in rats, mallard ducks, quail (mg/kg): >3600, >2000, >2000 orally (Crouse)

SPINOSAD Usage And Synthesis

Description

Spinosad is a naturally-occurring insecticide found in the the soil bacterium S. spinosa. It is a mixture of the macrocyclic lactones spinosyn A and spinosyn D , which act as agonists of insect nicotinic acetylcholinesterase receptors (nAChRs). Oral administration of spinosad induces toxicity in fruit flies including C. capitata, B. curcurbitae, and B. dorsalis (LC₅₀s = 2.8-4.2, 4.3-5.5, and 3.1-3.3 μg/ml, respectively) but has low toxicity in vertebrates. It also inhibits canine P-glycoprotein (P-gp; IC₅₀ = 0.2 μg/ml). Formulations containing spinosad have been used in the agricultural and veterinary control of insects.

Uses

Insecticide.

Definition

Isolated from Saccharopolyspora spinosa (Actinomycetes).

Hazard

A poison by inhalation. Moderately toxic by ingestion.

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