5-IODO-1,2,3-TRIMETHOXYBENZENE Chemical Properties

Melting point:

85-87°C

Boiling point:

312.6±42.0 °C(Predicted)

Density 

1.602±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

solid

color 

Pale yellow

Water Solubility 

Insoluble in water.

Sensitive 

Light Sensitive

BRN 

1529690

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-43

Safety Statements 

24/25-36/37-26

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29093090

MSDS

• Language:English Provider:ALFA

5-IODO-1,2,3-TRIMETHOXYBENZENE Usage And Synthesis

Uses

5-Iodo-1,2,3-trimethoxybenzene is used as a primary and secondary intermediate in organic synthesis.

Synthesis

GENERAL METHOD: Trifluoroborate (1 mmol) was dissolved in 3 mL of a mixture of DMF and water (2:1 volume ratio) and cesium triiodide (1 mmol) was added. The reaction mixture was stirred at 80 °C until the reaction was complete (see Table 3 for reaction times). After completion of the reaction, the reaction solution was diluted with 10 mL of ether. The aqueous layer was extracted twice with ether (5 mL), and the organic phases were combined and dried with anhydrous Na2SO4. After evaporation of the solvent, the residue was purified by silica gel column chromatography [eluent: solvent mixture of hexane (or pentane) and ethyl acetate (or ether)].

References

[1] Tetrahedron, 2012, vol. 68, # 19, p. 3738 - 3743

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