4-Fluorobenzotrifluoride Chemical Properties

Melting point:

−42-−41.7 °C(lit.)

Boiling point:

102-105 °C(lit.)

Density 

1.293 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.401(lit.)

Flash point:

51 °F

storage temp. 

Sealed in dry,2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Liquid

Specific Gravity

1.2930

color 

Clear colorless

Water Solubility 

Slightly soluble in water.

BRN 

1909390

CAS DataBase Reference

402-44-8(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1-fluoro-4-(trifluoromethyl)-(402-44-8)

EPA Substance Registry System

4-Fluorobenzotrifluoride (402-44-8)

Safety Information

Hazard Codes 

F,Xi,F+

Risk Statements 

11-36/37/38

Safety Statements 

16-26-33-24/25-7/9

RIDADR 

UN 1993 3/PG 2

WGK Germany 

3

Hazard Note 

Flammable/Irritant

TSCA 

T

HazardClass 

3

PackingGroup 

II

HS Code 

29039990

MSDS

• Language:English Provider:alpha,alpha,alpha,4-tetrafluorotoluene
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Fluorobenzotrifluoride Usage And Synthesis

Chemical Properties

Clear colourless to light yellow liquid

Uses

4-Fluorobenzotrifluoride was used in the synthesis of 2,2?-bis(trifluoromethylphenoxy)biphenyl via nucleophilic aromatic substitution reaction with 2,2?-biphenol, (S)-fluoxetine, potent inhibitor of neuronal serotonin-uptake and 1-aryloxy-2-substituted aminomethyltetrahydronaphthalene derivatives.

Synthesis Reference(s)

Tetrahedron, 49, p. 8129, 1993 DOI: 10.1016/S0040-4020(01)88032-7

4-Fluorobenzotrifluoride(402-44-8)Related Product Information

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• 1,4-Bis(trifluoromethyl)-benzene
• 1,2,4-Trimethylbenzene
• Benzotrifluoride
• Benzene
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• Diethylstilbestrol
• Mesitylene
• TRITON
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• 2'-FLUORO-5'-(TRIFLUOROMETHYL)ACETOPHENONE
• 2-FLUORO-5-(TRIFLUOROMETHYL)BENZYLAMINE
• OCTAFLUOROTOLUENE
• 2-FLUORO-5-(TRIFLUOROMETHYL)BENZYL ALCOHOL
• Fluorine