4-(TERT-BUTYL)-2,6-DIMETHYLANILINE Chemical Properties

Melting point:

29-29.5 °C

Boiling point:

96 °C

Density 

0.9321 g/cm3(Temp: 25 °C)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

4.63±0.10(Predicted)

Appearance

Colorless to light yellow Liquid

CAS DataBase Reference

42014-60-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

20/21/22-36/37/38-36

Safety Statements 

26-36/37/39

RIDADR 

2810

Hazard Note 

Irritant

HazardClass 

6.1

PackingGroup 

Ⅱ

HS Code 

2921420090

4-(TERT-BUTYL)-2,6-DIMETHYLANILINE Usage And Synthesis

Synthesis

5-(tert-butyl)-1,3-dimethyl-2-nitrobenzene (15 g, 0.072 mol) was mixed with stannous chloride (41 g, 0.216 mol) in 300 mL of ethanol and the reaction was heated at reflux for 24 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature and neutralized by slowly adding aqueous potassium hydroxide solution under stirring. Subsequently, the reaction mixture was extracted with ethyl acetate to separate the organic phase. The organic phase was purified by column chromatography to give 7 g of 4-tert-butyl-2,6-dimethyl-aniline ([Intermediate 8-b]) in 58% yield.

References

[1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987, p. 1 - 8
[2] Chemistry Letters, 1983, p. 1373 - 1374
[3] Journal of Chemical Research - Part S, 2000, # 6, p. 290 - 291
[4] Patent: KR2015/124677, 2015, A. Location in patent: Paragraph 0291; 0296-0299
[5] Organometallics, 2010, vol. 29, # 24, p. 6723 - 6731

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