3-Fluoropyridine-4-carboxylic acid Chemical Properties

Melting point:

251-254°C (dec.)

Boiling point:

360.0±22.0 °C(Predicted)

Density 

1.419±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

2.85±0.10(Predicted)

form 

solid

color 

White to off-white

BRN 

383678

InChIKey

POLXLLIQWDBJMD-UHFFFAOYSA-N

CAS DataBase Reference

393-53-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,F

Risk Statements 

36/37/38-10

Safety Statements 

26-36-16

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2933399990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

3-Fluoropyridine-4-carboxylic acid Usage And Synthesis

Synthesis

3-Fluoropyridine (25 g, 257 mmol) was slowly added dropwise to a solution of tetrahydrofuran (600 mL) containing butyl lithium (270 mmol) and diisopropylamine (27.4 g, 271 mmol) at -78 °C. The reaction mixture was stirred continuously at this temperature for 1 hour. Subsequently, crushed dry ice was added to the reaction system and gradually warmed to room temperature over 1 hour. Upon completion of the reaction, the pH of the reaction solution was adjusted to 5 with an aqueous solution of hydrogen chloride and acidified. The resulting precipitate was collected by filtration and dried. The final 3-fluoroisonicotinic acid (25.2 g, 179 mmol, 70% yield) was obtained as colorless crystals.

References

[1] Patent: WO2006/36015, 2006, A2. Location in patent: Page/Page column 121-122

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