2-Amino-5-nitrophenol
2-Amino-5-nitrophenol Basic information
- Product Name:
- 2-Amino-5-nitrophenol
- Synonyms:
-
- 3-nitro-6-aminophenol
- ncic55970
- rodolyba
- ursolyellowbrowna
- CI 76535
- 5-NITRO-O-AMINOPHENOL
- 5-NITRO-2-AMINOPHENOL
- 2-AMINO-5-NITROPENOL
- CAS:
- 121-88-0
- MF:
- C6H6N2O3
- MW:
- 154.12
- EINECS:
- 204-503-8
- Product Categories:
-
- Aromatic Phenols
- Phenol&Thiophenol&Mercaptan
- Intermediates of Dyes and Pigments
- Phenoles and thiophenoles
- Building Blocks
- C6 to C8
- Chemical Synthesis
- Organic Building Blocks
- Oxygen Compounds
- Phenols
- Mol File:
- 121-88-0.mol
2-Amino-5-nitrophenol Chemical Properties
- Melting point:
- 198-202 °C (dec.) (lit.)
- Boiling point:
- 322.46°C (rough estimate)
- Density
- 1.3617 (estimate)
- refractive index
- 1.6890 (rough estimate)
- pka
- 8.08±0.19(Predicted)
- form
- Crystalline Powder
- color
- Rust brown to brown
- Water Solubility
- insoluble
- BRN
- 972974
- CAS DataBase Reference
- 121-88-0(CAS DataBase Reference)
- IARC
- 3 (Vol. 57) 1993
- EPA Substance Registry System
- 2-Amino-5-nitrophenol (121-88-0)
Safety Information
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-68-20/21/22
- Safety Statements
- 26-36/37-45-36/37/39-36
- RIDADR
- 2811
- WGK Germany
- 2
- RTECS
- SJ6302500
- TSCA
- Yes
- HS Code
- 29222900
- Hazardous Substances Data
- 121-88-0(Hazardous Substances Data)
- Toxicity
- LD50 oral in rat: > 4gm/kg
MSDS
- Language:English Provider:4-Amino-3-hydroxynitrobenzene
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
2-Amino-5-nitrophenol Usage And Synthesis
Chemical Properties
Brown to rust Crystalline powder
Uses
Reactant for:• ;Diazotation and coupling reactions1• ;Preparation of biologically and pharmacologically active molecules2
Uses
2-Amino-5-nitrophenol is used in hair dyes and as an intermediate in preparing azo dyes.
Uses
2-Amino-5-nitrophenol has been used as starting material in the synthesis of series of (Z)-2-(substituted aryl)-N-(3-oxo-4-(substituted carbamothioyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl) hydrazine carboxamides, as semi permanent (nonoxidative) hair colorant and as toner in permanent (oxidative) hair dye products, in synthesis of series of 7-benzylamino-2H-1,4-benzoxazin-3(4H)-ones, anticonvulsant agents. Also used as a reactant for, diazotation and coupling reactions, preparation of biologically and pharmacologically active molecules. It is also applied in hair dyes and to make azo dyes.
General Description
Brown amorphous granules or powder. Melting point 198-202°C.
Air & Water Reactions
Is slowly oxidized by air at room temperature. Insoluble in water.
Reactivity Profile
2-Amino-5-nitrophenol is a reducing agent. Incompatible with strong oxidizing agents. Reacts slowly with oxygen in the air at room temperature. Stable at temperatures up to 140°F for two weeks when kept in the dark and under nitrogen. Stable under nitrogen for up to 24 weeks 77°F. Incompatible with strong bases . Incompatible with acid chlorides and acid anhydrides.
Fire Hazard
Flash point data for 2-Amino-5-nitrophenol are not available. 2-Amino-5-nitrophenol is probably combustible.
Carcinogenicity
The potential carcinogenicity of 2-amino-5-nitrophenol was tested by NTP by oral administration (gavage) in corn oil to F344/N rats (100 and 200 mg/kg) and B6C3F1 mice (400 and 800 mg/kg) for 2 years. There was some evidence of carcinogenic activity in low-dose male rats, as indicated by increased incidence of acinar cell adenomas of the pancreas. No evidence of carcinogenic activity was found among female rats and the low-dose groups of male and female mice. The poor survival rates in the high-dose male rats and high-dose male and female mice reduced the sensitivity for detecting potential carcinogenic response.
Purification Methods
Crystallise the phenol from water. [Beilstein 13 IV 803.]
2-Amino-5-nitrophenol Preparation Products And Raw materials
Preparation Products
Raw materials
2-Amino-5-nitrophenol(121-88-0)Related Product Information
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