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2-Amino-5-nitrophenol

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2-Amino-5-nitrophenol Basic information

Product Name:
2-Amino-5-nitrophenol
Synonyms:
  • 3-nitro-6-aminophenol
  • ncic55970
  • rodolyba
  • ursolyellowbrowna
  • CI 76535
  • 5-NITRO-O-AMINOPHENOL
  • 5-NITRO-2-AMINOPHENOL
  • 2-AMINO-5-NITROPENOL
CAS:
121-88-0
MF:
C6H6N2O3
MW:
154.12
EINECS:
204-503-8
Product Categories:
  • Aromatic Phenols
  • Phenol&Thiophenol&Mercaptan
  • Intermediates of Dyes and Pigments
  • Phenoles and thiophenoles
  • Building Blocks
  • C6 to C8
  • Chemical Synthesis
  • Organic Building Blocks
  • Oxygen Compounds
  • Phenols
Mol File:
121-88-0.mol
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2-Amino-5-nitrophenol Chemical Properties

Melting point:
198-202 °C (dec.)(lit.)
Boiling point:
322.46°C (rough estimate)
Density 
1.3617 (estimate)
refractive index 
1.6890 (rough estimate)
pka
8.08±0.19(Predicted)
form 
Crystalline Powder
color 
Rust brown to brown
Water Solubility 
insoluble
BRN 
972974
CAS DataBase Reference
121-88-0(CAS DataBase Reference)
IARC
3 (Vol. 57) 1993
EPA Substance Registry System
2-Amino-5-nitrophenol (121-88-0)
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-68-20/21/22
Safety Statements 
26-36/37-45-36/37/39-36
RIDADR 
2811
WGK Germany 
2
RTECS 
SJ6302500
TSCA 
Yes
HS Code 
29222900
Hazardous Substances Data
121-88-0(Hazardous Substances Data)
Toxicity
LD50 oral in rat: > 4gm/kg

MSDS

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2-Amino-5-nitrophenol Usage And Synthesis

Chemical Properties

Brown to rust Crystalline powder

Uses

Reactant for:• ;Diazotation and coupling reactions1• ;Preparation of biologically and pharmacologically active molecules2

Uses

2-Amino-5-nitrophenol is used in hair dyes and as an intermediate in preparing azo dyes.

General Description

Brown amorphous granules or powder. Melting point 198-202°C.

Air & Water Reactions

Is slowly oxidized by air at room temperature. Insoluble in water.

Reactivity Profile

2-Amino-5-nitrophenol is a reducing agent. Incompatible with strong oxidizing agents. Reacts slowly with oxygen in the air at room temperature. Stable at temperatures up to 140°F for two weeks when kept in the dark and under nitrogen. Stable under nitrogen for up to 24 weeks 77°F. Incompatible with strong bases . Incompatible with acid chlorides and acid anhydrides.

Fire Hazard

Flash point data for 2-Amino-5-nitrophenol are not available. 2-Amino-5-nitrophenol is probably combustible.

Carcinogenicity

The potential carcinogenicity of 2-amino-5-nitrophenol was tested by NTP by oral administration (gavage) in corn oil to F344/N rats (100 and 200 mg/kg) and B6C3F1 mice (400 and 800 mg/kg) for 2 years. There was some evidence of carcinogenic activity in low-dose male rats, as indicated by increased incidence of acinar cell adenomas of the pancreas. No evidence of carcinogenic activity was found among female rats and the low-dose groups of male and female mice. The poor survival rates in the high-dose male rats and high-dose male and female mice reduced the sensitivity for detecting potential carcinogenic response.

Purification Methods

Crystallise the phenol from water. [Beilstein 13 IV 803.]

2-Amino-5-nitrophenol Preparation Products And Raw materials

Preparation Products

Raw materials

2-Amino-5-nitrophenolSupplier