2-Amino-5-nitrophenol
2-Amino-5-nitrophenol Basic information
- Product Name:
- 2-Amino-5-nitrophenol
- Synonyms:
-
- 3-nitro-6-aminophenol
- ncic55970
- rodolyba
- ursolyellowbrowna
- CI 76535
- 5-NITRO-O-AMINOPHENOL
- 5-NITRO-2-AMINOPHENOL
- 2-AMINO-5-NITROPENOL
- CAS:
- 121-88-0
- MF:
- C6H6N2O3
- MW:
- 154.12
- EINECS:
- 204-503-8
- Product Categories:
-
- Aromatic Phenols
- Phenol&Thiophenol&Mercaptan
- Intermediates of Dyes and Pigments
- Phenoles and thiophenoles
- Building Blocks
- C6 to C8
- Chemical Synthesis
- Organic Building Blocks
- Oxygen Compounds
- Phenols
- Mol File:
- 121-88-0.mol
2-Amino-5-nitrophenol Chemical Properties
- Melting point:
- 198-202 °C (dec.)(lit.)
- Boiling point:
- 322.46°C (rough estimate)
- Density
- 1.3617 (estimate)
- refractive index
- 1.6890 (rough estimate)
- pka
- 8.08±0.19(Predicted)
- form
- Crystalline Powder
- color
- Rust brown to brown
- Water Solubility
- insoluble
- BRN
- 972974
- CAS DataBase Reference
- 121-88-0(CAS DataBase Reference)
- IARC
- 3 (Vol. 57) 1993
- EPA Substance Registry System
- 2-Amino-5-nitrophenol (121-88-0)
Safety Information
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-68-20/21/22
- Safety Statements
- 26-36/37-45-36/37/39-36
- RIDADR
- 2811
- WGK Germany
- 2
- RTECS
- SJ6302500
- TSCA
- Yes
- HS Code
- 29222900
- Hazardous Substances Data
- 121-88-0(Hazardous Substances Data)
- Toxicity
- LD50 oral in rat: > 4gm/kg
MSDS
- Language:English Provider:4-Amino-3-hydroxynitrobenzene
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
2-Amino-5-nitrophenol Usage And Synthesis
Chemical Properties
Brown to rust Crystalline powder
Uses
Reactant for:• ;Diazotation and coupling reactions1• ;Preparation of biologically and pharmacologically active molecules2
Uses
2-Amino-5-nitrophenol is used in hair dyes and as an intermediate in preparing azo dyes.
General Description
Brown amorphous granules or powder. Melting point 198-202°C.
Air & Water Reactions
Is slowly oxidized by air at room temperature. Insoluble in water.
Reactivity Profile
2-Amino-5-nitrophenol is a reducing agent. Incompatible with strong oxidizing agents. Reacts slowly with oxygen in the air at room temperature. Stable at temperatures up to 140°F for two weeks when kept in the dark and under nitrogen. Stable under nitrogen for up to 24 weeks 77°F. Incompatible with strong bases . Incompatible with acid chlorides and acid anhydrides.
Fire Hazard
Flash point data for 2-Amino-5-nitrophenol are not available. 2-Amino-5-nitrophenol is probably combustible.
Carcinogenicity
The potential carcinogenicity of 2-amino-5-nitrophenol was tested by NTP by oral administration (gavage) in corn oil to F344/N rats (100 and 200 mg/kg) and B6C3F1 mice (400 and 800 mg/kg) for 2 years. There was some evidence of carcinogenic activity in low-dose male rats, as indicated by increased incidence of acinar cell adenomas of the pancreas. No evidence of carcinogenic activity was found among female rats and the low-dose groups of male and female mice. The poor survival rates in the high-dose male rats and high-dose male and female mice reduced the sensitivity for detecting potential carcinogenic response.
Purification Methods
Crystallise the phenol from water. [Beilstein 13 IV 803.]
2-Amino-5-nitrophenol Preparation Products And Raw materials
Preparation Products
Raw materials
2-Amino-5-nitrophenol(121-88-0)Related Product Information
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