3-HYDROXY-3-PHENYL-PROPIONITRILE Chemical Properties

Boiling point:

306-307 °C (lit.)

Density 

1.112 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.5420(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,2-8°C

solubility 

soluble in Chloroform, Dichloromethane, Ethyl Acetate

form 

liquid

pka

13.00±0.20(Predicted)

color 

Colourless

Safety Information

WGK Germany 

3

HS Code 

2926907090

MSDS

• Language:English Provider:SigmaAldrich

3-HYDROXY-3-PHENYL-PROPIONITRILE Usage And Synthesis

Chemical Properties

Orange Oil

Uses

3-Phenyl-3-hydroxypropanenitrile (cas# 17190-29-3) is a compound useful in organic synthesis.

Definition

ChEBI: 3-hydroxy-3-phenylpropionitrile is a nitrile that is 3-phenylpropionitrile in which one of the methylene hydrogens at position 3 is replaced by a hydroxy group. It is a nitrile, a member of benzyl alcohols and a secondary alcohol. It is functionally related to a 3-phenylpropionitrile.

Synthesis Reference(s)

The Journal of Organic Chemistry, 48, p. 366, 1983 DOI: 10.1021/jo00151a017
Synthetic Communications, 24, p. 1433, 1994 DOI: 10.1080/00397919408011747
Tetrahedron Letters, 26, p. 155, 1985 DOI: 10.1016/S0040-4039(00)61867-1

General Description

3-Hydroxy-3-phenylpropionitrile, a β-hydroxynitrile, is an aryl substituted α-aminophenylaceronitrile. It can be obtained by reacting lithioacetonitrile with benzaldehyde via asymmetric 1,2-addition reaction.

3-HYDROXY-3-PHENYL-PROPIONITRILE(17190-29-3)Related Product Information

• 3-(O-CHLOROPHENYL)-3-HYDROXY-3-PHENYL PROPIONITRILE
• Phenylacetaldehyde
• Propionitrile
• (R)-(+)-3-HYDROXY-3-PHENYLPROPIONITRILE
• 3-HYDROXY-3-(4-METHOXYPHENYL)PROPANENITRILE
• 3-HYDROXY-3-PHENYL-PROPIONITRILE
• 2-[HYDROXY-(4-NITRO-PHENYL)-METHYL]-ACRYLONITRILE
• 2-[hydroxy(4-phenylphenyl)methyl]prop-2-enenitrile
• 3-HYDROXY-3-(3-METHYLPHENYL)PROPANENITRILE
• 2-[(3,4-dichlorophenyl)(hydroxy)methyl]prop-2-enenitrile
• (3-OXO-1,3-DIHYDRO-ISOBENZOFURAN-1-YL)-ACETONITRILE
• 2-[(4-bromophenyl)(hydroxy)methyl]prop-2-enenitrile
• 3-HYDROXY-3-(3-METHOXYPHENYL)PROPANENITRILE
• 2-[(dimethylamino)methyl]-3-hydroxy-3-phenylpropanenitrile
• (S)-3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPIONITRILE
• (S)-(-)-3-HYDROXY-3-PHENYLPROPIONITRILE
• AURORA KA-1727
• 3-METHYL-3-PHENYLOXIRANE-2-CARBONITRILE