ACETYL-DL-CARNITINE HYDROCHLORIDE
ACETYL-DL-CARNITINE HYDROCHLORIDE Basic information
- Product Name:
- ACETYL-DL-CARNITINE HYDROCHLORIDE
- Synonyms:
-
- (+/-)-3-ACETOXY-4-(TRIMETHYLAMMONIO)BUTYRATE HYDROCHLORIDE
- [+/-]-3-ACETOXY-4-(TRIMETHYLAMMONIO)BUTYRATE HYDROCHLORIDE
- ACETYL-DL-CARNITINE HYDROCHLORIDE
- (+/-)-ACETYLCARNITINE CHLORIDE
- acetyl-dl-carnitine hcl crystalline
- (±)-(2-acetoxy-3-carboxypropyl)trimethylammonium chloride
- Acetyl-DL-carnitineHCl
- Acetyl-DL-carnitinehydrochloridecrystalline
- CAS:
- 2504-11-2
- MF:
- C9H18ClNO4
- MW:
- 239.7
- EINECS:
- 2197093
- Product Categories:
-
- Cholinergics
- Lipid signaling
- Mol File:
- 2504-11-2.mol
ACETYL-DL-CARNITINE HYDROCHLORIDE Chemical Properties
- Melting point:
- 181 - 183°C
- storage temp.
- -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- Soluble to 100 mM in water
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 2504-11-2(CAS DataBase Reference)
MSDS
- Language:English Provider:SigmaAldrich
ACETYL-DL-CARNITINE HYDROCHLORIDE Usage And Synthesis
Uses
(±)-Acetylcarnitine Chloride is a drug absorption-enhancing agent in the gastrointestinal tract.
Biological Activity
(±)-acetylcarnitine chloride is an agonist for cholinergic.acetylcholine receptor (achr) is an integral membrane protein receptor for acetylcholine. there are two kinds of achrs: nicotinic acetylcholine receptors and muscarinic acetylcholine receptors.(±)-acetylcarnitine chloride is a cholinergic agonist and an intermediate in lipid metabolism [1]. in retinal ganglion cells, acetylcarnitine and acetylcholine inhibited gabaergic responses to exogenous gaba and gabaergic inhibitory postsynaptic currents [2].in dogs with coronary ligation, (-)-carnitine chloride (lcc) (300 mg/kg) and acetyl (-)-carnitine chloride (alcc) (300 mg/kg) inhibited the ventricular arrhythmia. also, lcc and alcc improved oxidative phosphorylation rate and the mitochondrial function [1]. in the mouse hot plate test, acetyl-l-carnitine (alcar) (100 mg/kg) exhibited analgesia. while, u-73122 and neomycin (the phospholipase c (plc) inhibitors) blocked the increase of the pain threshold induced by alcar. licl that impairing phosphatidylinositol synthesis antagonized the antinociception in a dose-dependent way. pma and pdbu (pkc activators) blocked the increase of the pain threshold in a dose-dependent way. these results suggested that alcar analgesia required the participation of the plc-ip3 pathway [3].
Biochem/physiol Actions
Weak cholinergic receptor agonist; intermediate in lipid metabolism.
Purification Methods
Recrystallise the chloride from isopropanol. Dry it over P2O5 under high vacuum. The S-betaine crystallises from EtOH/Et2O with m 145o(dec) and is hygroscopic; it has [] D -19.5o (c 6, H2O). [Krimberg & Wittandt Biochem Z 251 231 1932, Strack et al. Z Physiol Chem 238 191 1936, Beilstein 4 III 1630, 1632.]
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ACETYL-DL-CARNITINE HYDROCHLORIDE(2504-11-2)Related Product Information
- Palmitoyl-L-Carnitine Chloride
- HEXANOYL-L-CARNITINE CHLORIDE
- (+/-)-OCTANOYLCARNITINE CHLORIDE
- LINOLEOYL-L-CARNITINE CHLORIDE
- MYRISTOYL-L-CARNITINE CHLORIDE
- O-Acetyl-L-carnitine hydrochloride
- DECANOYL-L-CARNITINE CHLORIDE
- BUTYRYL-L-CARNITINE CHLORIDE
- ACETYL-D-CARNITINE CHLORIDE
- LAUROYL-L-CARNITINE CHLORIDE
- (3-CARBOXYPROPYL)TRIMETHYLAMMONIUM CHLORIDE
- DL-Carnitine
- L(-)-Carnitine hydrochloride
- L-carnitine
- DL-Carnitine hydrochloride
- ACETYL-DL-CARNITINE HYDROCHLORIDE
- DL-CAPROYLCARNITINE CHLORIDE
- DL-STEAROYL CARNITINE CHLORIDE