3',5'-Dichloroacetophenone Chemical Properties

Melting point:

26 °C

Boiling point:

82°C 0,1mm

Density 

1.304±0.06 g/cm3(Predicted)

refractive index 

1.5630 to 1.5670

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

color 

Colorless to Light yellow to Light orange

CAS DataBase Reference

14401-72-0(CAS DataBase Reference)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-25/26

HS Code 

29147000

3',5'-Dichloroacetophenone Usage And Synthesis

Chemical Properties

Light yellow liquid

Synthesis

General procedure for the synthesis of 1-(3,5-dichlorophenyl)ethanone from 3,5-dichloroiodobenzene (37.0 g, 136 mmol) and acetic anhydride: 3,5-dichloroiodobenzene, Pd2(dba)3 (1.5 g, 1.6 mmol), and lithium chloride (29.0 g, 682 mmol) were dissolved in 100 ml of DMF in a 500 ml round bottomed flask. Subsequently 64.0 ml of acetic anhydride and 47.0 ml of N-ethyl diisopropylamine were added to the reaction mixture. The reaction mixture was heated at 100°C for the reaction. After completion of the reaction, water was added to the mixture, extracted with ethyl acetate and the product was purified by column chromatography using ethyl acetate as eluent. 8 g of 1-(3,5-dichlorophenyl)ethanone was finally obtained.

References

[1] Patent: JP2015/212297, 2015, A. Location in patent: Paragraph 0106; 0107

3',5'-Dichloroacetophenone(14401-72-0)Related Product Information

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