2-Bromo-6-fluorobenzoic acid Chemical Properties

Melting point:

153-155°C

Boiling point:

286.1±25.0 °C(Predicted)

Density 

1.789±0.06 g/cm3(Predicted)

refractive index 

1.567-1.569

storage temp. 

Sealed in dry,Room Temperature

form 

Solid

pka

1.92±0.10(Predicted)

color 

White to Light yellow to Light orange

InChI

InChI=1S/C7H4BrFO2/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3H,(H,10,11)

InChIKey

MDAZJVAIZVUWDE-UHFFFAOYSA-N

SMILES

C(O)(=O)C1=C(F)C=CC=C1Br

CAS DataBase Reference

2252-37-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

36/37/38-36-25

Safety Statements 

37/39-26-45

RIDADR 

2811

WGK Germany 

3

HazardClass 

IRRITANT

PackingGroup 

Ⅲ

HS Code 

29163990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Bromo-6-fluorobenzoic acid Usage And Synthesis

Chemical Properties

White powder

Uses

2-Bromo-6-fluorobenzoic acid is an intermediate, mainly used in the industries such as medicine, agricultural chemicals at present.

Synthesis

The synthesis and preparation method of the 2-bromo-6-fluorobenzoic acid comprises the following steps: by using o-fluorobenzonitrile as an initial raw material, carrying out nitrification, nitroreduction, bromization, diazo-deamination and hydrolysis to synthesize the 2-bromo-6-fluorobenzoic acid.

References

[1] Organic Letters, 2009, vol. 11, # 5, p. 1051 - 1054
[2] Australian Journal of Chemistry, 2016, vol. 69, # 3, p. 307 - 313
[3] Synthesis, 2005, # 4, p. 617 - 621
[4] Tetrahedron Letters, 1996, vol. 37, # 36, p. 6551 - 6554
[5] ChemMedChem, 2010, vol. 5, # 10, p. 1693 - 1696

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