N-Methyl-2,2,2-trifluoroacetamide Chemical Properties

Melting point:

49-51 °C(lit.)

Boiling point:

156-157 °C(lit.)

Density 

1.3215 (estimate)

Flash point:

165 °F

storage temp. 

Inert atmosphere,Room Temperature

pka

11.54±0.46(Predicted)

form 

powder to crystal

color 

White to Almost white

Sensitive 

Hygroscopic

BRN 

1703392

InChI

InChI=1S/C3H4F3NO/c1-7-2(8)3(4,5)6/h1H3,(H,7,8)

InChIKey

IQNHBUQSOSYAJU-UHFFFAOYSA-N

SMILES

C(NC)(=O)C(F)(F)F

CAS DataBase Reference

815-06-5(CAS DataBase Reference)

NIST Chemistry Reference

Acetamide, 2,2,2-trifluoro-N-methyl-(815-06-5)

EPA Substance Registry System

Acetamide, 2,2,2-trifluoro-N-methyl- (815-06-5)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

RIDADR 

UN 1325 4.1/PG 2

WGK Germany 

3

F 

3-10-21

Hazard Note 

Irritant/Hygroscopic

TSCA 

T

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29241990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

N-Methyl-2,2,2-trifluoroacetamide Usage And Synthesis

Chemical Properties

WHITE CRYSTALS OR CRYSTALLINE POWDER

Uses

N-Methyltrifluoroacetamide is a useful synthetic intermediate. It is used to prepare electrophilic 11b-aryl derivs. of estradiol as steroidal affinity labels of the estrogen receptor a. It is also used to synthesize amino substituted derivatives of 5'-amino-5'-deoxy-5'-noraristeromycin as antiviral agent.

General Description

The high-resolution proton and fluorine resonance spectra of N-methyltrifluoroacetamide in tetrahydrofuran and acetone was studied.

N-Methyl-2,2,2-trifluoroacetamide(815-06-5)Related Product Information

• N-Methylformamide
• N-Methyldiethanolamine
• N-Methylolacrylamide
• Trifluoroacetamide
• Kresoxim-methyl
• Methanol
• N-Methyl-2-pyrrolidone
• N-Methylaniline
• Acetonitrile
• Trifluoroacetamidine
• Methyl acetate
• Methylparaben
• Paraquat dichloride
• 1-Methylimidazole
• N-Methylacetamide
• N,N-Dimethylformamide
• Basic Violet 1
• Bis(trimethylsilyl)trifluoroacetamide