LINOLEIC ACID SODIUM SALT
LINOLEIC ACID SODIUM SALT Basic information
- Product Name:
- LINOLEIC ACID SODIUM SALT
- Synonyms:
-
- 12-octadecadienoicacid(z,z)-sodiumsalt
- CIS-9,CIS-12-OCTADECADIENOIC ACID SODIUM SALT
- LINOLEIC ACID SODIUM SALT
- linoleic acid sodium
- sodium (9Z,12Z)-octadeca-9,12-dienoate
- (9Z,12Z)-9,12-Octadecadienoic acid sodium salt
- Linoleic acid sodium salt,cis-9,cis-12-Octadecadienoic acid sodium salt
- (Z,Z)-9,12-Octadecadienoic acid sodium salt
- CAS:
- 822-17-3
- MF:
- C18H33NaO2
- MW:
- 304.45
- EINECS:
- 212-491-0
- Mol File:
- 822-17-3.mol
LINOLEIC ACID SODIUM SALT Chemical Properties
- Melting point:
- 192 °C
- storage temp.
- -20°C
- solubility
- soluble in Ethanol
- form
- powder to crystal
- color
- White to Orange to Green
- biological source
- plant oil (safflower)
- InChIKey
- WYPBVHPKMJYUEO-NBTZWHCOSA-M
- EPA Substance Registry System
- 9,12-Octadecadienoic acid (9Z,12Z)-, sodium salt (822-17-3)
MSDS
- Language:English Provider:SigmaAldrich
LINOLEIC ACID SODIUM SALT Usage And Synthesis
Uses
Linoleic Acid Sodium Salt can be used for cell culture materials, fluidic device module, drug testing, and fluidic device
Biological Activity
Linoleic acid, as a component of acylglycosyl ceramides, plays a physiological role in maintaining the water permeability barrier of the skin. The deficiency of linoleic acid may cause poor growth or development, scaly dermatitis, and an impaired immune response in infants. It is used in cosmetic and personal care products. Linoleic acid is mainly used as emollients or moisturizers for skin, nails, and hair.
in vivo
Linoleate (in the form of high-linoleate safflower oil, 10% (w/w), p.o., dietary, 4 weeks) sodium preserves cardiolipin and attenuates mitochondrial dysfunction in the failing rat heart[3].
Linoleate (in the form of a diet containing 15% (w/w) safflower oil; p.o., through diet) sodium reduces the induction of fatty acid synthetase activity in rat liver[4].
Linoleate (in the form of linoleate-enriched safflower oil, 100 ppm, dietary) sodium increases arachidonic acid (20:4n-6) levels in the serum of mice with antigen-induced antibodies and allergic reactions[5].
Linoleate (in the form of linoleate-enriched safflower oil, corresponding to an 18:2n-6/18:3n-3 ratio of 127; dietary) sodium attenuates gastric mucosal damage induced by ethanol, ischemia/reperfusion, and water immersion stress in a rat experimental gastric ulcer model[6].
Linoleate sodium (1 mg/mouse; ip; 1 time) significantly increases the median survival of mice inoculated with EAT cells from 18 days to 48 days, and completely inhibited tumor growth in more than 40% of mice[7].
Linoleate (in the form of linoleate-rich safflower oil, 10% of the semi-purified diet; fed) sodium makes ICR mice more sensitive to pentobarbital, as manifested by a shorter onset of anesthetic effect and a longer duration of anesthetic[8].
Linoleate (in the form of linoleate-rich safflower oil corresponding to an 18:2n-6/18:3n-3 ratio of less than 0.1; fed) can reduce urine protein levels, plasma urea nitrogen levels, glomerular crescent formation, and fibrinoid necrosis in rats with crescent-type anti-glomerular basement membrane nephritis, while increasing the proportion of arachidonic acid (20:4n-6) in glomerular phospholipids[9].
| Animal Model: | Male lean SHHF rats; spontaneously hypertensive heart failure model[3] |
| Dosage: | High-linoleate safflower oil (HLSO), 10% (w/w) |
| Administration: | ad libitum for 4 weeks |
| Result: | Preserved L4CL and total CL to 90% of non-failing levels. Attenuated 17-22% decreases in state 3 mitochondrial respiration. Increased left ventricular fractional shortening significantly, and decreased plasma insulin levels. Augmented the production of several eicosanoid species in serum compared with the control and lard groups. |
IC 50
IL-8
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LINOLEIC ACID SODIUM SALT(822-17-3)Related Product Information
- Linoleic acid
- Ethyl nicotinate
- GLUCOTROPAEOLIN
- METHYL LINOLENATE
- MONOMYRISTIN
- Linolenic acid
- LINOLENIC ACID ETHYL ESTER
- gamma-Linolenic acid
- Valeric acid
- Hydroxyaluminum distearate
- Sodium nitrite
- METHYL LINOLEATE
- Sodium oleate
- SODIUM DILINOLEATE
- PELARGONIC ACID SODIUM SALT
- LINOLEIC ACID SODIUM SALT
- ENANTHIC ACID SODIUM SALT
- Sodium octanoate