1,2,4,5-Tetrafluorobenzene Chemical Properties

Melting point:

4 °C (lit.)

Boiling point:

90 °C (lit.)

Density 

1.344 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.407(lit.)

Flash point:

61 °F

storage temp. 

Sealed in dry,2-8°C

form 

clear liquid

color 

Colorless to Almost colorless

Specific Gravity

1.344

Water Solubility 

Not miscible or difficult to mix in water.

BRN 

1909052

InChI

InChI=1S/C6H2F4/c7-3-1-4(8)6(10)2-5(3)9/h1-2H

InChIKey

SDXUIOOHCIQXRP-UHFFFAOYSA-N

SMILES

C1(F)=CC(F)=C(F)C=C1F

CAS DataBase Reference

327-54-8(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1,2,4,5-tetrafluoro-(327-54-8)

Safety Information

Hazard Codes 

F,Xi

Risk Statements 

11-36/37/38

Safety Statements 

16-26-36/37/39-37/39-33-7/9

RIDADR 

UN 1993 3/PG 2

WGK Germany 

3

Hazard Note 

Flammable/Irritant

HazardClass 

3

PackingGroup 

II

HS Code 

29039990

Storage Class

3 - Flammable liquids

Hazard Classifications

Eye Irrit. 2
Flam. Liq. 2
Skin Irrit. 2
STOT SE 3

MSDS

• Language:English Provider:1,2,4,5-Tetrafluorobenzene
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1,2,4,5-Tetrafluorobenzene Usage And Synthesis

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

It is employed as intermediate in organic synthesis. It is also used as pharmaceutical intermediate.

Synthesis Reference(s)

The Journal of Organic Chemistry, 29, p. 3042, 1964 DOI: 10.1021/jo01033a061

Synthesis

First, 2,4-dichlorofluorobenzene was used as a raw material and nitrated in the presence of 98% concentrated sulfuric acid at 20-40℃ to introduce a nitro group at a specific position on the benzene ring, generating 2,4-dichloro-5-fluoronitrobenzene. After purification by toluene extraction, solvent recovery under normal pressure, and vacuum distillation (120-130℃/8 mmHg), anhydrous potassium fluoride was used as the fluorinating agent to carry out a nucleophilic aromatic substitution reaction (Halex reaction) in a polar aprotic solvent at a high temperature of 180-200℃. The fraction with a boiling point of 88-92℃ was collected in time by "reaction-distillation". Through the simultaneous substitution of two chlorine atoms and the nitro group by fluorine atoms, 1,2,4,5-tetrafluorobenzene was finally obtained.

1,2,4,5-Tetrafluorobenzene(327-54-8)Related Product Information

• Florfenicol
• 4-Fluorobenzaldehyde
• 2,3,4,5,6-PENTAFLUOROSTYRENE
• 1,4-DIBROMOTETRAFLUOROBENZENE
• 2,3,5,6-TETRAFLUOROANISOLE
• 2',3',4',5',6'-PENTAFLUOROACETOPHENONE
• 2,3,4,5,6-PENTAFLUOROBENZOPHENONE
• Decafluorobiphenyl
• DECAFLUOROBENZOPHENONE
• Bromopentafluorobenzene
• tetrafluorobenzene
• Transfluthrin
• FENFLURAMINE
• DIPHENYL(PENTAFLUOROPHENYL)PHOSPHINE
• hexafluorobenzene
• Pentafluorobenzene
• 2,3,4,5,6-PENTAFLUOROANISOLE
• 2,3,5,6-TETRAFLUOROTOLUENE