PUROMYCIN AMINONUCLEOSIDE Chemical Properties

Melting point:

235℃ (Decomposition)

Boiling point:

436.08°C (rough estimate)

Density 

1.2131 (rough estimate)

refractive index 

1.7000 (estimate)

Flash point:

>110°(230°F)

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

H₂O: 50 mg/mL, clear, slightly yellow

form 

liquid

pka

13.26±0.70(Predicted)

color 

White

Water Solubility 

Soluble in water at 50mg/ml. May require heating

BRN 

93902

Stability:

Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.

InChIKey

RYSMHWILUNYBFW-GRIPGOBMSA-N

EPA Substance Registry System

Adenosine, 3'-amino-3'-deoxy-N,N-dimethyl- (58-60-6)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

48/22

WGK Germany 

3

RTECS 

AU7337000

F 

10-21

TSCA 

Yes

HS Code 

29419090

MSDS

• Language:English Provider:SigmaAldrich

PUROMYCIN AMINONUCLEOSIDE Usage And Synthesis

Description

Puromycin aminonucleoside (58-60-6) is the nucleoside moiety of puromycin (Cat.# 10-2100) which does not inhibit protein synthesis or induce apoptosis.1?It acts as a glomerular epithelial cell toxin2 and as such is a useful tool for producing animal models of nephropathy3,4, or puromycin aminonucleoside nephrosis (1-2.5 mg/100g rat body weight)5. Active in vivo.

Chemical Properties

White crystal

Uses

Puromycin aminonucleoside is a semi-synthetic derivative of puromycin which lacks the methoxyphenylalanyl moiety. Puromycin aminonucleoside is the key intermediate in the synthesis of semi-synthetic analogues of puromycin. It does not inhibit protein synthesis or induce apoptosis, but exhibits antitumour properties. Puromycin aminonucleoside-induced nephrosis is a well-described model of human idiopathic nephrotic syndrome, suppressing integrin expression in cultured glomerular epithelial cells.

Uses

Puromycin Aminonucleoside is an aminonucleoside portion of the antibiotic puromycin.

Definition

ChEBI: Puromycin derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring.

Safety Profile

An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx,.

References

1) Chow et al. (1995), Reevaluation of the role of de novo protein synthesis in rat thymocyte apoptosis; Exp. Cell Res., 216 149 2) Krishnamurti et al. (2001), Puromycin aminonucleoside suppresses integrin expression in cultured glomerular epithelial cells; J. Am. Soc. Nephrol., 12 758 3) Egashira et al. (2006), Tryptophan-niacin metabolism in rat with puromycin aminonucleoside-induced nephrosis; Int. J. Vitam. Nutr. Res., 76 28 4) Hagiwara et al. (2006), Mitochondrial dysfunction in focal segmental glomerulosclerosis of puromycin aminonucleoside nephrosis; Kidney Int., 69 1146 5) Lowenborg et al. (2000), Glomerular function and morphology in puromycin aminonucleoside nephropathy in rats; Nephrol. Dial. Transplant, 15 1547

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