METHYSTICIN
METHYSTICIN Basic information
- Product Name:
- METHYSTICIN
- Synonyms:
-
- 5,6-Dihydro-4-methoxy-6-(3,4-(methylenedioxy)styryl)-2H-pyran-2-one
- METHYSTICIN
- KAVAHIN
- KAVATIN
- (±)-Methystici)
- Methysticin (DL-Methysticin
- 2H-Pyran-2-one, 6-[(1E)-2-(1,3-benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-
- METHYSTICIN USP/EP/BP
- CAS:
- 20697-20-5
- MF:
- C15H14O5
- MW:
- 274.27
- Mol File:
- 20697-20-5.mol
METHYSTICIN Chemical Properties
- Melting point:
- 129-131 °C
- Boiling point:
- 496.5±45.0 °C(Predicted)
- Density
- 1.31±0.1 g/cm3(Predicted)
METHYSTICIN Usage And Synthesis
Uses
DL-Methysticin is a useful synthetic compound.
in vivo
The kavalactone Methysticin (6 mg/kg) is administered once a week for a period of 6 months to 6 month old transgenic APP/Psen1 mice by oral gavage. Methysticin treatment activates the Nrf2 pathway in the hippocampus and cortex of mice. The Aβ deposition in brains of Methysticin-treated APP/Psen1 mice is not altered compared to untreated mice. However, Methysticin treatment significantly reduces microgliosis, astrogliosis and secretion of the pro-inflammatory cytokines TNF-α and IL-17A. Methysticin treatment results in a significant activation of the Nrf2/ARE pathway in hippocampus and the cortex but not in the midbrain and cerebellum of ARE-luciferase reporter gene mice. Methysticin treatment significantly increases the expression of both genes compared to untreated animals[2].
IC 50
CYP1A1
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