Schisantherin A
Schisantherin A Basic information
- Product Name:
- Schisantherin A
- Synonyms:
-
- SCHISANTHERIN A 98.0% BY HPLC
- Schisantherin A (Gomisin-C
- Gomisin C(Schisantherin A)
- Schisantherin A
- SCHISANTHERINGOMISIN
- Gomisin, 98%, from Schisandra chinensis
- Benzo[3,4]cycloocta[1,2-f][1,3]benzodioxole-5,6-diol, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, 5-benzoate, (5S,6S,7S,13aS)-
- (5S,6S,7S,13aS)-5,6,7,8-Tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethylbenzo[3,4]cycloocta[1,2-f]
- CAS:
- 58546-56-8
- MF:
- C30H32O9
- MW:
- 536.57
- Product Categories:
-
- Inhibitors
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Heterocycles
- Mol File:
- 58546-56-8.mol
Schisantherin A Chemical Properties
- Melting point:
- 110～112℃
- Boiling point:
- 675.6±55.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly, Sonicated)
- form
- Solid
- pka
- 13.70±0.60(Predicted)
- color
- White to Off-White
- Water Solubility
- insoluble in water
Safety Information
- Safety Statements
- 24/25
- HS Code
- 29329990
Schisantherin A Usage And Synthesis
Chemical Properties
Rectangular crystals (ethanol), mp 122°C-124°C, [α]D23 -175° (c=0.12, chloroform). Soluble in benzene, chloroform, acetone, soluble in methanol, ethanol, insoluble in petroleum ether, insoluble in water. Seven biphenyl cyclooctenoid lignans with transaminase-lowering activity were isolated from the ethanol extract of Schisandra chinensis kernels, including deoxyschisandrin, schisandrin, schisandrin, schisandrin, schisandrin, schisandrinol ethyl, schisandrin ester A and schisandrin ester ethyl. All seven components have the effect of lowering SGPT, promoting hepatic gluconeogenesis and prolonging pentobarbital sleep time. Schisandra chinensis ester B had the strongest SGPT-lowering effect, Schisandra chinensis alcohol B had the most significant effect in promoting hepatic gluconeogenesis, and Schisandra chinensis prolonged pentobarbital sleep time most prominently.
Uses
Schisantherin A?is a ligand from Schisandra chinensis. It is capable of?suppressing interleukin-1β-induced inflammation in human chondrocytes by inhibiting NF-κB and MAPKs activation.
Definition
ChEBI: Schisantherin A is a tannin.
in vivo
Schisantherin A, a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera, has been reported to possess varied beneficial pharmacological effects. Schisantherin A protects lipopolysaccharide-induced acute respiratory distress syndrome in mice through inhibiting NF-κB and MAPKs signaling pathways. Pretreatment with Schisantherin A markedly ameliorates LPS-induced histopathologic changes and decreases the levels of TNF-α, IL-6 and IL-1β in the BALF. In addition, the phosphorylation of NF-κB p65, IκB-α, JNK, ERK and p38 induced by LPS are suppressed by Schisantherin A. The lung wet/dry weight ratio is evaluated at 7 h after the intranasal instillation of LPS. The results show that there are no differences between control group and Schisantherin A (40 mg/kg) group (p>0.05). LPS causes a significant increase in lung wet/dry weight ratio (p<0.01) compared with the control group. Schisantherin A dose-dependently decreases the lung wet/dry weight ratio (p<0.05) compared to those in the LPS group[1].
target
ROS | NO | NOS | MAPK | PI3K | GSK-3 | IL Receptor | PGE | TNF-α | COX | ERK | p38MAPK | JNK | NF-kB | Beta Amyloid | Akt
IC 50
p65
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Schisantherin A(58546-56-8)Related Product Information
- Schisandrin A
- Meclofenoxate hydrochloride
- 2-(Dimethylamino)ethyl (4-chlorphenoxy)acetate
- Gabexate mesylate
- Gomisin A
- SCHIZANDRIN B
- SCHISANTHERIN C 98+% HPLC
- schisanhenol
- WUWEIZISU C
- Schisandrin
- Benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-1-ol, 5,6,7,8-tetrahydro-2, 3,13-trimethoxy-6,7-dimethyl-, stereoisomer
- SCHISANTHERIN B,SCHISANTHERIN B 98.0% BY HPLC
- Schisantherin E
- 4-HYDROXY-4'-METHOXYBIPHENYL
- 3-(3,4-DIMETHOXYPHENYL)-1-PROPANOL
- Masoprocol
- 2,2'-Biphenol
- Gomisin B(Schisantherin B)