DIMETHYL 2,6-NAPHTHALENEDICARBOXYLATE Chemical Properties

Melting point:

187-193 °C(lit.)

Boiling point:

347.16°C (rough estimate)

Density 

1.2379 (rough estimate)

vapor pressure 

0Pa at 25℃

refractive index 

1.5389 (estimate)

Flash point:

232°C

storage temp. 

Sealed in dry,Room Temperature

form 

powder to crystal

color 

White to Almost white

Water Solubility 

Soluble in hot toluene (very faint turbidity). Insoluble in water.

BRN 

987259

InChI

InChI=1S/C14H12O4/c1-17-13(15)11-5-3-10-8-12(14(16)18-2)6-4-9(10)7-11/h3-8H,1-2H3

InChIKey

GYUVMLBYMPKZAZ-UHFFFAOYSA-N

SMILES

C1=C2C(C=C(C(OC)=O)C=C2)=CC=C1C(OC)=O

LogP

3.5 at 25℃

CAS DataBase Reference

840-65-3(CAS DataBase Reference)

EPA Substance Registry System

Dimethyl 2,6-naphthalenedicarboxylate (840-65-3)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

TSCA 

Yes

HS Code 

2917.39.7000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

DIMETHYL 2,6-NAPHTHALENEDICARBOXYLATE Usage And Synthesis

Uses

Dimethyl naphthalene-2,6-dicarboxylate is used as a pharmaceutical intermediate.

Flammability and Explosibility

Non flammable

Synthesis

To a round bottom flask was added 20 g of 2,6-naphthalenedicarboxylic acid dissolved in 150 mL of methanol and 15 mL of concentrated sulfuric acid was added as a catalyst. The reaction mixture was heated to reflux for 24 hours to complete the esterification reaction. Upon completion of the reaction, the mixture was slowly poured into 500 mL of ice water to quench the reaction. The resulting white precipitate was collected by diafiltration and washed with plenty of water to remove residual acid and methanol. Finally, the product was dried in a vacuum drying oven to give 20 g of dimethyl 2,6-naphthalenedicarboxylate in 89% yield.

References

[1] Patent: CN103864711, 2016, B. Location in patent: Paragraph 0102; 0103; 0104
[2] RSC Advances, 2014, vol. 4, # 35, p. 18100 - 18107

DIMETHYL 2,6-NAPHTHALENEDICARBOXYLATE(840-65-3)Related Product Information

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