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2-TERT-BUTYL-1,1,3,3-TETRAMETHYLGUANIDINE

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2-TERT-BUTYL-1,1,3,3-TETRAMETHYLGUANIDINE Basic information

Product Name:
2-TERT-BUTYL-1,1,3,3-TETRAMETHYLGUANIDINE
Synonyms:
  • 2-TERT-BUTYL-1,1,3,3-TETRAMETHYL-GUANIDI
  • 2-TERT-BUTYL-1,1,3,3-TETRAMETHYLGUANIDINE
  • Guanidine, N''-(1,1-diMethylethyl)-N,N,N',N'-tetraMethyl-
  • 2-tert-Butyl-1,1,3,3-tetraMethylguanidine >=97.0% (GC)
  • BTMG
  • EOS-61801
  • N''-tert-butyl-N,N,N',N'-tetramethylguanidine
  • 3H-Pyrazol-3-one,1,2-dihydro-1-(5-methylethyl)-
CAS:
29166-72-1
MF:
C9H21N3
MW:
171.28
Product Categories:
  • Guanidines
  • Nitrogen Compounds
  • Organic Building Blocks
Mol File:
29166-72-1.mol
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2-TERT-BUTYL-1,1,3,3-TETRAMETHYLGUANIDINE Chemical Properties

Boiling point:
88-89 °C/43 mmHg (lit.)
Density 
0.85
refractive index 
n20/D 1.457
Flash point:
65 °C
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
clear liquid
pka
13.81±0.70(Predicted)
color 
Colorless to Light yellow
BRN 
2352408
InChIKey
YQHJFPFNGVDEDT-UHFFFAOYSA-N
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Safety Information

Hazard Codes 
C
Risk Statements 
22-34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3267 8/PG 2
WGK Germany 
3
10-34
HS Code 
2925.29.7000

MSDS

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2-TERT-BUTYL-1,1,3,3-TETRAMETHYLGUANIDINE Usage And Synthesis

Uses

2-tert-Butyl-1,1,3,3-tetramethylguanidine (Barton′s base) is an excellent alternative to traditional inorganic bases for promoting the coupling reaction.

Preparation

To an ovendried, 500-mL, three-necked, round-bottomed flask, equipped with a nitrogen inlet with gas bubbler, magnetic stirring bar, thermometer, condenser, and a 250-mL dropping funnel, were added triphosgene (14.8 g, 0.05 mol) and anhydrous toluene (120 mL). The mixture was kept under argon and cooled to ca. 10 C° with the aid of an external ice bath. A solution of N,N,N,N-tetramethylurea (18.0 mL, 0.15 mol) in dry toluene (50 mL) was then slowly added over a period of 30 min. After completion of the addition, the mixture was allowed to warm to ambient temperature, and stirring was continued for a further 1 h. During this time, a white precipitate formed, consisting of the Vilsmeier salt. Then, tert-butylamine (47.3 mL, 0.45 mol) was slowly added to the mixture over a period of 30 min. After completion of the addition, the mixture was heated under reflux for 5 h and then cooled to room temperature. Anhydrous diethyl ether (200 mL) was added and the white precipitate was quickly removed by filtration. This precipitate had to be collected as quickly as possible to avoid hydrolysis to the starting urea. The precipitate turns pale-yellow if hydrolysis is occurring. In some instances, additional diethyl ether (300 mL) was needed to ensure complete transfer of the solids to the filtration apparatus. The precipitate was washed with a further quantity of anhydrous diethyl ether (300 mL) (the filtrate must be colorless, indicating that all impurities have been removed) and immediately dissolved in aqueous 25% sodium hydroxide solution (100 mL). The mixture was then extracted with diethyl ether (3 × 300 mL). The combined organic layers were dried (potassium carbonate), filtered, and the solvent was removed under reduced pressure. The resulting colorless liquid was purified by distillation (bp 88–89 C°/36 mmHg) to afford 18.7 g (73%) of 2-tertbutyl- 1,1,3,3-tetramethylguanidine 1779.

General Description

2-tert-Butyl-1,1,3,3-tetramethylguanidine (Barton′s base) is an excellent alternative to traditional inorganic bases for promoting the coupling reaction.

2-TERT-BUTYL-1,1,3,3-TETRAMETHYLGUANIDINESupplier

Suzhou Highfine Biotech Co., Ltd Gold
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0512-69209928 18306209922
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Creasyn Finechem(Tianjin) Co., Ltd.
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022-83946278 13820503911
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sales@creasyn.com
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2-TERT-BUTYL-1,1,3,3-TETRAMETHYLGUANIDINE(29166-72-1)Related Product Information