5-Chlorosalicylaldehyde Chemical Properties

Melting point:

100-102 °C(lit.)

Boiling point:

217.69°C (rough estimate)

Density 

1.2683 (rough estimate)

refractive index 

1.5812 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

Crystalline Powder

pka

7.73±0.18(Predicted)

color 

White to very slightly yellow

Sensitive 

Air Sensitive

BRN 

636632

LogP

2.570 (est)

CAS DataBase Reference

635-93-8(CAS DataBase Reference)

NIST Chemistry Reference

5-Chloro-2-hydroxy benzaldehyde(635-93-8)

EPA Substance Registry System

Benzaldehyde, 5-chloro-2-hydroxy- (635-93-8)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

26-36-24/25-36/37/39

RIDADR 

UN2811/6.1/PG III

WGK Germany 

3

RTECS 

VN5450000

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29130000

MSDS

• Language:English Provider:5-Chlorosalicylic aldehyde
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

5-Chlorosalicylaldehyde Usage And Synthesis

Chemical Properties

white to very slightly yellow crystalline powder

Uses

5-Chlorosalicyaldehyde is a useful synthetic intermediate and a key precursor to a variety chelating agents.5-Chlorosalicyaldehyde is used to synthesize imine resveratrol (R150000) derivatives as multi-targeted agents against Alzheimer's disease.

Synthesis Reference(s)

Synthetic Communications, 20, p. 609, 1990 DOI: 10.1080/00397919008244911
Tetrahedron Letters, 15, p. 3463, 1974

Purification Methods

Steam distil it, then crystallise it from aqueous EtOH or *C6H6 (m 100o). It forms complexes with Cu2+ and Fe2+ . [Beilstein 8 H 53, 8 II 45, 8 III 181, 8 IV 224.]

5-Chlorosalicylaldehyde(635-93-8)Related Product Information

• Salicylaldehyde
• 1-Chloro-2-methylpropane
• N-Chlorosuccinimide
• 3-Chloropivaloyl chloride
• Paraldehyde
• Chlorocyclohexane
• 1-Nonanal
• 3,3',4',5-TETRACHLOROSALICYLANILIDE
• METHYL 5-CHLORO-2-METHOXYBENZOATE
• 6-CHLOROCHROMAN-4-ONE
• 6,8-DICHLORO-3-FORMYLCHROMONE
• 5-Chloro-2-hydroxybenzoic acid
• 3-BROMO-5-CHLOROSALICYLALDEHYDE
• 3-BROMO-5-CHLORO-2,6-DIMETHOXYBENZOIC ACID
• 2-Ethoxy-4-amino-5-chlorobenzoic acid
• 5-Chloro-2-methoxybenzoic acid
• Methyl 5-chloro-2-hydroxybenzoate
• Difluorochloromethane