ANTI-CDK4
ANTI-CDK4 Basic information
- Product Name:
- ANTI-CDK4
- Synonyms:
-
- RABBIT ANTI-CDK4
- ANTI-HUMAN CDK4 (CT)
- ANTI-HUMAN CDK4 (NT)
- ANTI-CDK4
- ANTI-CDK4 (AB-2), HUMAN
- ANTI-CDK4 (AB-2) MOUSE MAB
- ANTI-CDK4 (AB-3), HUMAN
- ANTI-CDK4 (AB-4), HUMAN
- MW:
- 0
- Product Categories:
-
- Antibodies to Cyclins and CDKsAntibodies
- CB to CNAntibodies for Kinase/Phosphatase Biology
- Cyclic-Dependent Kinase (CDK)Antibodies
- Alphabetical Index
- Antibodies for Cell Cycle
- Cell Biology
- Clone Index
- D
- Serine/Threonine Kinase Antibodies
- Mol File:
- Mol File
ANTI-CDK4 Chemical Properties
- storage temp.
- −20°C
- form
- buffered aqueous solution
ANTI-CDK4 Usage And Synthesis
Uses
Monoclonal Anti-Cdk4 antibody was used in:
- immunoprecipitation of human melanoma cell line.
- immunofluorescence of fibrosarcoma cells.
- western blot analysis
- immunofluorescence
- immunohistochemistry
Uses
Anti-CDK4 (AB2) antibody produced in rabbit is suitable for western blotting at a concentration of 1 μg/ml.
Uses
Rabbit Anti-CDK4 (AB1) antibody can be used for western blot assays at 1μg/ml.
General Description
Cdk4 exists, in part, as a multi-protein complex with a D-type cyclin, proliferating cell nuclear antigen (PCNA) and a protein inhibitor, p21Cip1. Cdk4 associates separately with p16, particularly in cells lacking a functional retinoblastoma protein.
Biochem/physiol Actions
In association with cyclins, cyclin-dependent kinases (CDKs) forms active kinase complexes which is responsible for regulating cell cycle progression in eukaryotic cells. Within the complexes, the CDKs serves a catalytic protein kinase activity. This catalytic activity is regulated by two mechanisms: protein phosphorylation and association of regulatory subunits.