Soticlestat
Soticlestat Basic information
- Product Name:
- Soticlestat
- Synonyms:
-
- Soticlestat
- TAK-935
- Methanone, [2,4'-bipyridin]-3-yl[4-hydroxy-4-(phenylmethyl)-1-piperidinyl]-
- OV935
- Inhibitor,CYP46A1,inhibit,cholesterol,24-hydroxylase,OV 935,Soticlestat,NMDA,antiepileptic,TAK935,CYPs,epilepsy,TAK 935,Cytochrome P450,OV-935
- 2,4’-Bipyridin]-3-yl(4-benzyl-4-hydroxy-1-piperidyl)methanone
- Soticlestat/TAK-935/OV935
- 2,4'-Bipyridin]-3-yl(4-benzyl-4-hydroxypiperidin-1-yl)methanone
- CAS:
- 1429505-03-2
- MF:
- C23H23N3O2
- MW:
- 373.45
- Mol File:
- 1429505-03-2.mol
Soticlestat Chemical Properties
- solubility
- DMSO: soluble
- form
- A solid
- color
- White to off-white
Soticlestat Usage And Synthesis
Uses
Soticlestat (TAK-935; OV935) is a first-in-class, potent, selective, and orally active cholesterol 24-hydroxylase (CH24H) inhibitor. Soticlestat has the potential for epilepsy syndromes research[1][2].
in vivo
Soticlestat treatment lowers brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduceds premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%. Soticlestat can suppress potassium-evoked extracellular glutamate elevations in the hippocampus[1].
| Animal Model: | Amyloid precursor protein and presenilin 1 (APP/PS1-Tg) mice (7-week-old)[1] |
| Dosage: | 10 mg/kg |
| Administration: | Oral administration; once daily; for 1 days, 3 days and 7 days |
| Result: | Lowered brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduced premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%. |
References
[1] Toshiya Nishi, et al. Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice. Sci Rep. 2020 Oct 13;10(1):17081. DOI:10.1038/s41598-020-74036-6
[2] Krista Eschbach, et al. Stiripentol for the treatment of seizures in Dravet syndrome. Expert Rev Clin Pharmacol. 2019 May;12(5):379-388. DOI:10.1080/17512433.2019.1605904
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