6-Methylthioguanine Chemical Properties

Melting point:

235.5°C

Density 

1.403 (estimate)

refractive index 

1.4606 (estimate)

storage temp. 

-20°C Freezer

solubility 

DMSO (Slightly), Methanol (Slightly, Sonicated)

form 

solid

color 

White to Off-White

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-37/38-41

Safety Statements 

24/25-39-26

WGK Germany 

3

HS Code 

29335995

MSDS

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6-Methylthioguanine Usage And Synthesis

Chemical Properties

off-white crystalline powder

Uses

2-Amino-6-methylmercaptopurine is a 2-amino-6-alkyldithiopurine that has been used with other 6-position carbon analogues to study brain specific diazepam binding.

Uses

As a metabolite of 2’-Deoxy-6-thio Guanosine (D281650) and 6-Thioguanine, 6-Methylthioguanine can be used as an effective immunosuppressant and anticancer agent, however chronic exposure can be mutagenic in human cells as long-term use of thiopurines was found to be associated with a significantly increased risk of various types of cancer.

Definition

ChEBI: 6-methylthioguanine is a metabolite of thioguanine, a drug used in cancer chemotherapy. It has a role as a human xenobiotic metabolite. It is a member of 2-aminopurines and a thiopurine. It is functionally related to a tioguanine.

Biochem/physiol Actions

2-Amino-6-methylmercaptopurine is synthesized from 6-mercaptopurine by the S methylation activity of thiopurine methyl transferase (TMPT) enzyme.

6-Methylthioguanine(1198-47-6)Related Product Information

• 8-AZA-6-HYDROXY-2-MERCAPTOPURINE
• 6-thioinosine-5'-triphosphate
• 6,8-DIHYDROXY-2-METHYLMERCAPTOPURINE
• 2-Amino-6-mercaptopurine-13C2,15N
• 6-N-HEPTYLMERCAPTOPURINE
• 1,9-DIHYDRO-6H-PURINE-6-THIONE
• 2-AMINO-9-(2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL)-6-THIOPURINE
• 6-(Methylthio)purine
• 2-AMINO-6-HYDROXY-8-MERCAPTOPURINE
• 1,7,8,9-tetrahydro-8-thioxo-6H-purin-6-one
• 6-METHYLMERCAPTOPURINE RIBOSIDE
• 6-Thioguanosine hydrate
• 2-MERCAPTOPURINE
• 6-METHYL-D3-MERCAPTOPURINE
• 2,6-Dithiopurine
• 1H-Imidazole-4-carboxylic acid
• 6-thioinosine 5'-monophosphate
• 6-thioinosine 2',3',5'-triacetate