E3 ligase Ligand-Linker Conjugates 17
E3 ligase Ligand-Linker Conjugates 17 Basic information
- Product Name:
- E3 ligase Ligand-Linker Conjugates 17
- Synonyms:
-
- E3 ligase Ligand-Linker Conjugates 17
- E3 Ligase Ligand-Linker Conjugates 20 (TFA)
- Cereblon Ligand -Linker Conjugates 2 TFA
- Pomalidomide Related Compound 6 Triflate
- N-(8-Aminooctyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide 2,2,2-trifluoroacetate
- N-(8-aminooctyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide trifluoroacetate
- Thalidomide-O-amido-C8-NH2 trifluoroacetate
- Acetamide, N-(8-aminooctyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-, 2,2,2-trifluoroacetate (1:1)
- CAS:
- 1950635-16-1
- MF:
- C25H31F3N4O8
- MW:
- 572.54
- Mol File:
- 1950635-16-1.mol
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E3 ligase Ligand-Linker Conjugates 17 Chemical Properties
- storage temp.
- 2-8°C
- form
- Solid
- color
- White to off-white
- InChIKey
- AJVLNIUPDHKOPS-UHFFFAOYSA-N
- SMILES
- O=C(C(F)(F)F)[O-].O=C(COC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)NCCCCCCCC[NH3+]
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E3 ligase Ligand-Linker Conjugates 17 Usage And Synthesis
Uses
Thalidomide-O-amido-C8-NH2 TFA (Cereblon Ligand -Linker Conjugates 2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
IC 50
Cereblon
References
[1] James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.
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E3 ligase Ligand-Linker Conjugates 17(1950635-16-1)Related Product Information
- N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt
- E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate
- E3 ligase Ligand-Linker Conjugates 5 Free Base
- Thalidomide-O-amido-C3-NH2 (TFA)
- E3 Ligase Ligand-Linker Conjugates 19
- E3 Ligase Ligand-Linker Conjugates 1
- E3 ligase Ligand-Linker Conjugates 14
- 4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione