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5-Chloropyrimidin-2-amine

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5-Chloropyrimidin-2-amine Basic information

Product Name:
5-Chloropyrimidin-2-amine
Synonyms:
  • TIMTEC-BB SBB005486
  • 5-CHLORO-2-PYRIMIDINAMINE
  • 2-AMINO-5-CHLOROPYRIMIDINE
  • 5-chloropyrimidin-2-amine
  • 2-Pyrimidinamine, 5-chloro- (9CI)
  • 5-chlorpyrimidin-2-amin
  • 5-chloro-2-pyrimidinylamine
  • 5-chloro-pyrimidin-2-ylamine
CAS:
5428-89-7
MF:
C4H4ClN3
MW:
129.55
EINECS:
226-581-2
Product Categories:
  • Heterocycle-Pyrimidine series
  • Heterocyclic Building Blocks
  • PYRIMIDINE
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Pyrimidines
  • PyrimidinesHeterocyclic Building Blocks
  • Biochemistry
  • Nucleobases and their analogs
  • Nucleosides, Nucleotides & Related Reagents
  • Building Blocks
  • Halogenated Heterocycles
Mol File:
5428-89-7.mol
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5-Chloropyrimidin-2-amine Chemical Properties

Melting point:
235-238 °C (lit.)
Boiling point:
314.6±34.0 °C(Predicted)
Density 
1.437±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
powder to crystal
pka
1.93±0.10(Predicted)
color 
White to Almost white
BRN 
110914
InChIKey
OQZMDDKDHRIGDY-UHFFFAOYSA-N
CAS DataBase Reference
5428-89-7(CAS DataBase Reference)
NIST Chemistry Reference
2-Amino-5-chloropyrimidine(5428-89-7)
EPA Substance Registry System
2-Pyrimidinamine, 5-chloro- (5428-89-7)
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
22-41
Safety Statements 
26-36/37
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
UV6329500
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
HS Code 
29335990

MSDS

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5-Chloropyrimidin-2-amine Usage And Synthesis

Uses

5-Chloropyrimidin-2-amine is an useful reagent of research interest in the preparation of JAK2 inhibitors for the treatment of myeloproliferative disorders and SIRT2 inhibitors for the treatment of Huntington''s disease.

Synthesis Reference(s)

Journal of the American Chemical Society, 64, p. 567, 1942 DOI: 10.1021/ja01255a030

5-Chloropyrimidin-2-amine Preparation Products And Raw materials

Preparation Products

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