2,6-Difluoroaniline Chemical Properties

Boiling point:

51-52 °C/15 mmHg (lit.)

Density 

1.199 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.508(lit.)

Flash point:

110 °F

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

solubility 

Chloroform, Ethyl Acetate (Slightly)

form 

Liquid

pka

1.81±0.10(Predicted)

color 

Clear yellow to brown

Specific Gravity

1.28

Water Solubility 

Slightly soluble in water.

BRN 

2802697

Stability:

Hygroscopic

InChIKey

ODUZJBKKYBQIBX-UHFFFAOYSA-N

CAS DataBase Reference

5509-65-9(CAS DataBase Reference)

NIST Chemistry Reference

2,6-Difluoroaniline(5509-65-9)

EPA Substance Registry System

2,6-Difluoroaniline (5509-65-9)

Safety Information

Hazard Codes 

Xn,Xi,F

Risk Statements 

10-20/21/22-36/37/38

Safety Statements 

36-36/37/39-26-23-16-16/23/26/36/37/39-24/25

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

F 

8-10-23

Hazard Note 

Irritant

HazardClass 

3

PackingGroup 

III

HS Code 

29214210

MSDS

• Language:English Provider:2,6-Difluorobenzenamine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2,6-Difluoroaniline Usage And Synthesis

Chemical Properties

clear yellow to brown liquid

Uses

2,6-Difluoroaniline is an important chemical in the sythesis technology for high-efficiency insecticide.

Uses

2,6-Difluoroaniline was used in the synthesis of:

• N-2,6-difluorophenyl-5-methoxy-1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamide, herbicidal compound
• series of 2,6,9-trisubstituted purine inhibitors of p38α kinase
• substituted phenylthiomorpholine dioxide, an active pharmaceutical intermediate

Uses

2,6-Difluoroaniline and several related primary amines are oxidized in chloroform by peroxybenzoic acid to the corresponding nitroso compounds. For example, treatment of 2,6-difluoroaniline with sodium azide can obtain 4-fluoro-2,1,3-benzoxadiazole, and the product is nitrified to obtain 7-nitro derivatives[1]. 2,6-Difluoroaniline is an important raw material and intermediate in organic synthesis, medicine, pesticides, dyes and other fields.

References

[1] Nunno L, et al. Oxidation of substituted anilines to nitroso-compounds. J. Chem. Soc. C, 1970; 9: 1433-1434.

2,6-Difluoroaniline(5509-65-9)Related Product Information

• N,N-Dimethylaniline
• 2-Fluoroaniline
• Diphenylamine
• 2,4,5-Trifluoroaniline
• 4-(Trifluoromethoxy)aniline
• 3,5-Difluoroaniline
• N,N-Dimethyl-1,4-phenylenediamine
• Sodium diphenylamine-4-sulfonate
• 4-Fluoroaniline
• 2,6-Difluorobenzylamine
• 2,3,6-TRIFLUOROANILINE
• 3,4-Difluoroaniline
• 2,3,4,6-TETRAFLUORONITROBENZENE
• 2,6-DIFLUOROPHENYL ISOCYANATE
• 4-AMINO-2,3,5,6-TETRAFLUOROBENZOIC ACID
• 4-AMINO-2,3,5,6-TETRAFLUOROBENZAMIDE
• PENTAFLUORONITROBENZENE
• 2,4,6-Trifluoroaniline