2-[(2-amino-5-methylph2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium saltenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n CAS#: 73630-23-6

2-[(2-amino-5-methylph2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium saltenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n Basic information

Product Name:

2-[(2-amino-5-methylph2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium saltenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n

Synonyms:

QUIN-2
QUIN 2, TETRAPOTASSIUM SALT
2-[(2-AMINO-5-METHYLPHENOXY)METHYL]-6-METHOXY-8-AMINO-QUINOLINE-N,N,N',N'-TETRAACETIC ACID TETRAPOTASSIUM SALT
2-[[2-BIS-(CARBOXYMETHYL)AMINO-5-METHYLPHENOXY]-METHYL]-6-METHOXY-8-BIS-(CARBOXYMETHYL)AMINOQUINOLINE TETRAPOTASSIUM SALT
2-[[2-BIS(CARBOXYMETHYL)AMINO-5-METHYLPHENOXY]METHYL]-6-METHOXY-8-BIS(CARBOXYMETHYL)AMINOQUINOLINE, 4K
2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium salt
2-[(2-Amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-N,N,Nμ,Nμ-tetraacetic acid tetrapotassium salt, 2-{[2-Bis-(carboxymethyl)amino-5-methylphenoxy]-methyl}-6-methoxy-8-bis-(carboxymethyl)aminoquinoline tetrapotassium salt
N-[2-[[8-[Bis(carboxymethyl)amino]-6-methoxy-2-quinolinyl]methoxy]-4-methylphenyl]-N-(carboxymethyl)glycine tetrapotassium salt

CAS:

73630-23-6

MF:

C26H28KN3O10

MW:

581.62

Product Categories:

Quinoline

Mol File:

73630-23-6.mol

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2-[(2-amino-5-methylph2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium saltenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n Chemical Properties

Melting point:: >250℃
RTECS: MB8303000
storage temp.: 2-8°C
solubility: H2O: soluble10mg/mL
form: powder
color: Light yellow
Water Solubility: Soluble in water at 10mg/ml
λmax: 353 nm, 333 nm
Merck: 13,8130
BRN: 5374262
Biological Applications: Calcium indicator; cadmium indicator; iron indicator; lanthanum indicator; zinc indicator; identifying taste modulators

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Safety Information

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 3-8-10

MSDS

Language:English Provider:SigmaAldrich

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2-[(2-amino-5-methylph2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium saltenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n Usage And Synthesis

Description

Quin-2 is a high-affinity fluorescent calcium indicator (K_d = 115 nM for calcium). It displays high selectivity for calcium, as it is not affected by sodium gradients, membrane potential, or intracellular pH. High affinity probes like quin-2 are ideal for monitoring low levels of calcium, as are found in resting cells. Loadings of up to 2 mM quin-2 are without serious toxic effects, so quin-2 may be used to buffer intracellular calcium transients. Excitation/emission maxima for quin-2 are 339 and 492 nm, respectively.

Uses

2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium salt can be used as a fluorescent highly selective Ca2+ indicator exhibiting fast uptake and release of Ca2+. Used as a calibration substance in the measurement of cytoplasmic free calcium.

Uses

QUIN 2, Tetrapotassium Salt is a useful fluorescing calcium indicator. It can also be used in biological study of practical aspects of measuring intracellular calcium signals with fluorescent indicators.

General Description

Binding of Ca²⁺ to QUIN 2 leads to a major shift in UV absorption spectrum and a twenty-fold enhancement in fluorescence quantum yield. TPEN (Cat. No. 616394) can be used in conjunction with QUIN 2 to reduce heavy-metal quenching of QUIN 2 fluorescence in cells. Spectral properties in the presence of low calcium concentrations (ex. 354 nm, em. 510 nm) differ from those during high calcium conditions (ex. 332 nm, em. 505 nm).

Biochem/physiol Actions

Primary TargetCalcium Probes

2-[(2-amino-5-methylph2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium saltenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,nSupplier

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Email: market03@meryer.com

Wuhan DKY Technology Co.,Ltd.

Tel: 27-81302488 18007166089
Email: info@dkybpc.com

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Email: info@efebio.com

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn

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2-[(2-amino-5-methylph2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrapotassium saltenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n(73630-23-6)Related Product Information