CNT2 inhibitor-1 Chemical Properties

Boiling point:

807.5±75.0 °C(Predicted)

Density 

1.57±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : 75 mg/mL (167.24 mM)

form 

Solid

pka

13.07±0.70(Predicted)

color 

Off-white to light yellow

CNT2 inhibitor-1 Usage And Synthesis

Uses

CNT2 inhibitor-1 is a potent concentrative nucleoside transporter 2 Inhibitor (CNT2), with an IC50 of 640 nM for hCNT2.

Biological Activity

Primary Target
hCNT2', 'Reversible: yes', 'Target IC50: 640 nM in COS-7 cells

References

[1] Tatani K, et al. Identification of 8-aminoadenosine derivatives as a new class of human concentrative nucleoside transporter 2 inhibitors. ACS Med Chem Lett. 2015 Jan 28;6(3):244-8. DOI:10.1021/ml500343r