4-(2-Aminoethyl)benzenesulfonamide Chemical Properties

Melting point:

150-152 °C (lit.)

Boiling point:

387.4±44.0 °C(Predicted)

Density 

1.2581 (rough estimate)

vapor pressure 

0Pa at 25℃

refractive index 

1.5690 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

10.16±0.10(Predicted)

form 

Solid

color 

White

Water Solubility 

15.5g/L at 20℃

LogP

-3.1 at 19.8℃

CAS DataBase Reference

35303-76-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

C,Xi,Xn

Risk Statements 

34-22-36/37/38-20/21/22

Safety Statements 

45-36/37/39-26-36-24/25

RIDADR 

UN3259

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

8

PackingGroup 

III

HS Code 

29350090

MSDS

• Language:English Provider:4-(2-Aminoethyl)benzenesulfonamide
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
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4-(2-Aminoethyl)benzenesulfonamide Usage And Synthesis

Uses

4-(2-Aminoethyl)benzenesulfonamide is used as the starting material in the synthesis of Des(5-methylpyrazinecarbonyl) trans-4-Methyl Glipizide (D292605); a degradation product of Glimepiride (G410150) which is a sulfonylurea hypoglycemic agent and an antidiabetic. 4-(2-Aminoethyl)benzenesulfonamide is also used as a reagent in the synthesis of deorphaning pyrrolopyrazines as potent multi-target antimalarial agents.

Chemical Properties

white to yellowish crystalline powder

Uses

4-(2-Aminoethyl)benzenesulfonamide was used to develop a model system to study the implementation of a microfluid chip required for Fourier transform measurements of biochemical interactions.

General Description

The human hepatocellular carcinoma (HCC) cells were treated with its inhibitor 4-(2-aminoethyl)benzenesulfonamide.

Flammability and Explosibility

Not classified

4-(2-Aminoethyl)benzenesulfonamide(35303-76-5)Related Product Information

• Phenethyl isocyanate
• 3-Ethyl-2,5-Dihydro-4-Methyl-2-Oxo-N-(2-Phenylethyl)-1h-Pyrrole-1-Carboxamide
• GLIMEPIRIDE RELATED COMPOUND C (20 MG) (GLIMEPIRIDE URETHANE)
• 4-12-00-02470 (Beilstein Handbook Reference)
• Glimepiride Impurity 19
• 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide
• trans-4-Methylcyclohexyl amine
• methyl hydrogen sulphate
• Glimepiride Impurity 2
• Meta-GliMepiride IMpurity
• GliMepiride EP IMpurity J
• Benzenesulfonamide, 3-(2-aminoethyl)- (9CI)
• trans-4-Methycyclohexyl isocyanate
• ortho-GliMepiride IMpurity
• [[4-[2-[[(3-Ethyl-2,5-dihydro-4-methyl-2-oxo-1H-pyrrol-1-yl)carbonyl]amino]ethyl]phenyl]sulfonyl]-carbamic acid ethyl ester
• cis-Glimepiride
• Glimepiride
• Glimepiride Impurity 30