PORPHOBILINOGEN Chemical Properties

Melting point:

174-177℃

Boiling point:

479℃

Density 

1.421

Flash point:

243℃

storage temp. 

-20°C

solubility 

Aqueous Base (Slightly), Acetonitrile (Slightly), DMSO (Slightly)

pka

4.22±0.10(Predicted)

form 

powder

color 

light yellow to pink

Merck 

13,7681

BRN 

220051

EPA Substance Registry System

Porphobilinogen (487-90-1)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

8-10

MSDS

• Language:English Provider:SigmaAldrich

PORPHOBILINOGEN Usage And Synthesis

Uses

An intermediate in the biosynthesis of Heme, found in the urine of patients with acute porphyria.

Definition

ChEBI: Porphobilinogen is a dicarboxylic acid that is pyrole bearing aminomethyl, carboxymethyl and 2-carboxyethyl substituents at positions 2, 3 and 4 respectively. It has a role as a metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a member of pyrroles, a dicarboxylic acid and an aralkylamino compound. It is a conjugate acid of a porphobilinogen(1-).

Biochem/physiol Actions

Intermediate in the biosynthesis of heme.

Purification Methods

Porphobilinogen recrystallises as the monohydrate (pink crystals) from dilute NH4 OAc solutions of pH 4, and is dried in vacuo. The hydrochloride monohydrate has m 165-170o(dec) (from dilute HCl). [Jackson & MacDonald Can J Chem 35 715 1957, Westall Nature 170 614 1952, Bogarad J Am Chem Soc 75 3610 1953, Beilstein 22/14 V 210.]

PORPHOBILINOGEN(487-90-1)Related Product Information

• porphobilinogen oxygenase
• Porphobilinogen synthase, 5-Aminolevulinate Hydrolyase (adding 5-aminolevulinate and cyclizing),PORPHOBILINOGEN SYNTHASE
• 3-ETHYL-1H-PYRROLE
• (1H-PYRROL-2-YL)METHANAMINE
• 2,4-Dimethyl-3-ethyl-1H-pyrrole
• 3,4-DIETHYLPYRROLE
• PORPHOBILINOGEN
• 2,4-Dimethylpyrrole
• 3-(PYRROL-3-YL)-PROPIONIC ACID
• 3-METHYLPYRROLE
• 5-Methyl-pyrrole-3-propionic acid
• (PYRROL-3-YL)-ACETIC ACID
• 3,4-DIMETHYLPYRROLE