Indeloxazine hydrochloride Chemical Properties

Melting point:

169-170°; mp 155-156°

storage temp. 

Sealed in dry,Room Temperature

Safety Information

RIDADR 

3249

HazardClass 

6.1(b)

PackingGroup 

III

Toxicity

LD50 in mice (mg/kg): 47 i.v. (Tachikawa)

Indeloxazine hydrochloride Usage And Synthesis

Description

Indeloxazine hydrochloride is a nootropic indicated for the treatment of senile dementia. In animal models indeloxazine reportedly enhances brain energy metabolism and monoamine content; its claimed protective effect on ischemia-induced amnesia is supported by the prolonged step-through latency in passive avoidance tests.

Originator

Yamanouchi (Japan)

Uses

Antidepressant.

brand name

Elen

Metabolic pathway

After oral administration of indeloxazine hydrochloride to rats, two conjugates, which are labile to a- glucosidase hydrolysis but refractory to b-glucosidase, are isolated from the urine and identified as a-D- glucopyranosides of trans-4-(2-morpholinylmethoxy)- 1,2-indandiol and trans-6-[[(1,2-dihydroxy-4- indanyl)oxy]-methyl]-3-morpholinone.

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