Triethyl acetyl citrate Chemical Properties

Melting point:

-42°C

Boiling point:

228-229 °C/100 mmHg (lit.)

Density 

1.136 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.439(lit.)

Flash point:

>230 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Soluble 1 in 140 of water; miscible with acetone, ethanol, and propan-2-ol.

color 

Colourless

Odor

odorless

BRN 

1804947

LogP

2.170 (est)

CAS DataBase Reference

77-89-4(CAS DataBase Reference)

NIST Chemistry Reference

1,2,3-Propanetricarboxylic acid, 2-acetoxy-, triethyl ester(77-89-4)

EPA Substance Registry System

1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, triethyl ester (77-89-4)

Safety Information

Safety Statements 

23-24/25

WGK Germany 

1

RTECS 

GE8225000

HS Code 

2918150000

MSDS

• Language:English Provider:2-(Acetyloxy)-1,2,3-propanetricarboxylic acid triethyl ester
• Language:English Provider:SigmaAldrich

Triethyl acetyl citrate Usage And Synthesis

Chemical Properties

Acetyltriethyl citrate occurs as a clear, odorless, practically colorless oily liquid.

Uses

ATEC is produced by the reaction of citric acid triethyl ester with acetic acid anhydride. It is used as a solvent plasticizer for cellulose nitrate and cellulose acetate.

Uses

Triethyl O-Acetylcitrate is used in the preparation of poly(lactic) acid biodegradable and flexible films, acting as a plasticizer. Also used in the synthesis of control-release capsules containing polymeric coatings.

Definition

Aqueous-based pharmaceutical coat- ings.

Production Methods

Acetyltriethyl citrate is prepared by the esterification of citric acid with ethanol followed by acylation with acetic anhydride.

General Description

Certified pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Triethyl 2-acetylcitrate is widely used in hydrophilic adhesives for medications and in biodegradable composition for papermaking and nonwoven production.

Pharmaceutical Applications

Acetyltriethyl citrate is used to plasticize polymers in formulated pharmaceutical coatings. The coating applications include capsules, tablets, beads and granules for taste masking, immediate release, sustained-release and enteric formulations. It is also used in diffusion-controlled release drug delivery systems.

Safety

Acetyltriethyl citrate is used in oral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritating material. However, ingestion of large quantities may be harmful.
LD₅₀ (cat, oral): 8.5 g/kg
LD₅₀ (mouse, IP): 1.15 g/kg
LD₅₀ (rat, oral): 7 g/kg

storage

Acetyltriethyl citrate should be stored in dry, closed containers at temperatures not exceeding 388℃. When stored in accordance with these conditions, acetyltriethyl citrate is a stable product.

Incompatibilities

Acetyltriethyl citrate is incompatible with strong alkalis and oxidizing materials.

Regulatory Status

Approved in the USA for direct food contact in food films.

Triethyl acetyl citrate (77-89-4)Related Product Information

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