Pomalidomide-PEG4-CO2H
Pomalidomide-PEG4-CO2H Basic information
- Product Name:
- Pomalidomide-PEG4-CO2H
- Synonyms:
-
- POMALIDOMIDE-PEG4-CO 2 H
- Pomalidomide-PEG4-CO2H
- Pomalidomide-PEG4-COOH
- 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid
- Thalidomide-NH-PEG4-C2-COOH
- Propanoic acid, 3-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-
- 1-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]-3,6,9,12-tetraoxapentadecan-15-oic Acid
- 1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
- CAS:
- 2138440-81-8
- MF:
- C24H31N3O10
- MW:
- 521.52
- Product Categories:
-
- peg
- Mol File:
- 2138440-81-8.mol
Pomalidomide-PEG4-CO2H Chemical Properties
- Boiling point:
- 773.6±60.0 °C(Predicted)
- Density
- 1.385±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 4.28±0.10(Predicted)
Pomalidomide-PEG4-CO2H Usage And Synthesis
Uses
Protein degrader builiding block Pomalidomide-PEG4-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition and E3 ligase ligand.
storage
Desiccate at RT
Pomalidomide-PEG4-CO2HSupplier
- Tel
- 0510-83588313-802 18800520310;
- sales@chemshuttle.com
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Tel
- QQ:65489617 15618227136
- info@SuperLan-chem.com
- Tel
- 025-58851090 13611564524
- lwan@aikonchem.com
- Tel
- +86-156-80926068 +86-15680926068
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Pomalidomide-PEG4-CO2H(2138440-81-8)Related Product Information
- E3 Ligase Ligand-Linker Conjugates 1
- POMALIDOMIDE-PEG2-CO2H
- Pomalidomide-PEG1-azide
- Pomalidomide-O-C4-NH2
- Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]-
- Pomalidomide-PEG3-N3
- Pomalidomide-PEG6-butyl iodide
- Pomalidomide-PEG5-CO2H
- POMALIDOMIDE-PEG1-CO2H
- Pomalidomide-PEG3-Amine HCl salt
- Pomalidomide-PEG3-CO2H
- 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
- E3 Ligase Ligand-Linker Conjugates 22
- Pomalidomide-PEG2-butyl iodide
- Pomalidomide-PEG4-azide
- Pomalidomide-PEG2-N3
- E3 ligase Ligand-Linker Conjugates 50
- POMALIDOMIDE-PEG1-ALKYNE